Results 101 to 110 of about 1,415,651 (391)

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

Psychological interventions in asthma [PDF]

, 2015
Asthma is a multifactorial chronic respiratory disease characterised by recurrent episodes of airway obstruction. The current management of asthma focuses principally on pharmacological treatments, which have a strong evidence base underlying their use ...
A Brewin, A Morice, AU Khan, AU Khan, BA Alexander, C Nickel, C Put, CE Blixen, CJ Ross, D Kohen, D Marriage, E Zairina, G Epstein, GD Parry, GH Guyatt, H Kotses, H Powell, H-C Deter, J Dahl, J Erskine, J Garrett, J Groen, J Hockemeyer, J Yorke, J Yorke, JM Perrin, JM Smyth, JR Smith, JR Smith, KA Long, L Nathell, L Osman, LW Freeman, M Castro, M Gabriela Pérez, M Henry, MA Weingarten, ME Ford, MJ Wagaman, MR George, MZ Wamboldt, P Lehrer, P Paudyal, PH Mayo, PM Lehrer, PM Lehrer, PM Lehrer, R Hock, R Yoon, RJ Lieshout Van, T Ritz, TC Ewer, TM Kelso, TM Kelso, VE Murphy, VT Colland, Y Hua-Bin   +56 more
core   +1 more source

“Unidos Hablemos” – description of a virtual conference series to engage the Hispanic and Latino community in asthma and COVID-19 education and research

Research Involvement and Engagement
Background Inequity in asthma and COVID-19 outcomes and research among Hispanic or Latino individuals is well established. Patient centered outcomes research (PCOR) may help address these inequalities.
Vivian Hernandez-Trujillo, Mary Hart, Rose Marie Ramos, Lynda Mitchell, Alex Colon Moya, Dorothy Delarosa, Margie Lorenzi, Marcela Gieminiani, Donna D. Gardner   +8 more
doaj   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

(Correcting) misdiagnoses of asthma: A cost effectiveness analysis [PDF]

, 2011
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Amanda Sumner, BN Awadh, Douglas Coyle, HM Sharpe, K Bahadori, Katherine Vandemheen, KB Weiss, L McKnight-Eily, LC O'Dowd, MD Krahn, MG Cisternas, MK Campbell, Ontario Drug Benefit Formulary/Comparative Drug Index, P Kenny, R Jin, RB Haynes, S Diaz-Lobato, S Kamble, SD Aaron, Shawn Aaron, Smita Pakhale, SP Corrigan, Statistics Canada, VP Luks, WJ Ungar   +24 more
core   +4 more sources

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.

New England Journal of Medicine, 2016
BACKGROUND The Amish and Hutterites are U.S. agricultural populations whose lifestyles are remarkably similar in many respects but whose farming practices, in particular, are distinct; the former follow traditional farming practices whereas the latter ...
Michelle M. Stein, C. Hrusch, Justyna Gozdz, C. Igartua, V. Pivniouk, Sean E Murray, J. Ledford, Mauricius Marques Dos Santos, Rebecca L. Anderson, N. Metwali, J. Neilson, R. Maier, J. Gilbert, M. Holbreich, P. Thorne, F. Martinez, E. von Mutius, D. Vercelli, C. Ober, A. Sperling   +19 more
semanticscholar   +1 more source

Multiple electrolyte imbalances and mixed acid-base disorder posing a diagnostic dilemma: a case report

Journal of Medical Case Reports, 2020
Background In clinical practice, both the history and laboratory testing are paramount to making an accurate diagnosis. Situations in which laboratory findings and patient history are not congruent pose a diagnostic dilemma.
Fortune O. Alabi, Christopher O. Alabi, Rafaela G. Basso, Nadia Lakhdar, Adebanke O. Oderinde   +4 more
doaj   +1 more source

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

Advanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu, Chengya Huang, Xin Li, Haonan Yu, Yuefeng Xia, Kun Liu, Xingji You, Jingxiang Wu   +7 more
wiley   +1 more source

Role of Biologics in Asthma

American Journal of Respiratory and Critical Care Medicine, 2019
&NA; Patients with severe uncontrolled asthma have disproportionally high morbidity and healthcare utilization as compared with their peers with well‐controlled disease.
M. McGregor, James G. Krings, Parameswaran Nair, M. Castro   +3 more
semanticscholar   +1 more source

Latin American chronic urticaria registry (CUR) contribution to the understanding and knowledge of the disease in the region

World Allergy Organization Journal, 2019
Chronic urticaria (CU) has a widespread spectrum on causal or exacerbating factors, clinical manifestations, therapeutic response and quality of life affectation. Registries are useful tools in several real-life diagnosis and management approach.We aimed
René Maximiliano Gómez, Edgardo Jares, Mario Sanchez Borges, Ilaria Baiardini, G Walter Canonica, Gianni Passalacqua, Allen Kaplan, Patricia Latour, Eduardo Costa, Gabriela Dias, Jorge Lavrut, A.M. Agar Muñoz, E. De los Ríos, B. Del Río Navarro, M.C. Díaz, R.A. Fisher, J.C. Ivancevich, A. Mendoza, B. Morfin Maciel, G. Mortera Ortiz, Ramírez, D.I. Aragón, H. Ratti Sisa, N. Rodríguez, O. Rodríguez, J. Rodríguez Galindo, M.I. Rojo, P. Slulitell, S.S. Spinelli, I. Tinoco, A. Zanachi   +30 more
doaj