Results 101 to 110 of about 1,522,848 (395)

Multiscale Profiling of Nanoscale Metal‐Organic Framework Biocompatibility and Immune Interactions

Advanced Healthcare Materials, EarlyView.
A multi‐scale, hierarchical ‘Safety‐by‐Design’ pipeline combining machine learning, ex vivo human blood assays, and in vivo models enables the systematic immunotoxicity and biocompatibility profiling of nanoscale metal‐organic frameworks, accelerating their safe clinical translation. Abstract The clinical translation of metal‐organic frameworks (MOFs) –
Yunhui Zhuang, Bárbara B. Mendes, Dhruv Menon, Jhenifer Oliveira, Xu Chen, Fatma Demir Duman, João Conniot, Sergio Mercado, Xiewen Liu, Shi‐Yuan Zhang, João Conde, Rachel E. Hewitt, David Fairen‐Jimenez   +12 more
wiley   +1 more source

Vital Signs: Asthma in Children — United States, 2001–2016

MMWR. Morbidity and mortality weekly report, 2018
BACKGROUND Asthma is the most common chronic lung disease of childhood, affecting approximately 6 million children in the United States. Although asthma cannot be cured, most of the time, asthma symptoms can be controlled by avoiding or reducing exposure
Hatice S. Zahran, C. Bailey, S. Damon, P. Garbe, P. Breysse   +4 more
semanticscholar   +1 more source

Inhalability and Bioactivity of Spray‐Dried versus Pressurized Gas eXpanded Liquid Technology‐Processed Yeast Beta‐Glucan Microparticles for Anti‐Fibrotic Therapies

Advanced Healthcare Materials, EarlyView.
PGXTEC) liquid technology is utilized to develop highly respirable yeast beta‐glucan (YBG) microparticles for the treatment of pulmonary fibrosis. Compared to conventionally processed spray‐dried YBG, PGXTEC‐YBG exhibits greatly improved aerodynamic properties, enhanced pro‐fibrotic macrophage uptake, and effective downregulation of pro‐fibrotic ...
Nate Dowdall, Safaa Naiel, Quan Zhou, Pareesa Ali, Tamana Rubina Yousof, Emily Wong, Ricardo Couto, Byron Yépez, Bernhard Seifried, Paul Moquin, Rod Rhem, Myrna Dolovich, Martin Rainer Kolb, Kjetil Ask, Todd Hoare   +14 more
wiley   +1 more source

Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition

BMC Biology
Background T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function.
Jana Koch, Alessandra Ruggia, Carina Beha, Irina Wipf, Damir Zhakparov, Patrick Westermann, Svenja Schmelzer, Anja Heider, Klemens Fröhlich, Katja Baerenfaller   +9 more
doaj   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Multiple electrolyte imbalances and mixed acid-base disorder posing a diagnostic dilemma: a case report

Journal of Medical Case Reports, 2020
Background In clinical practice, both the history and laboratory testing are paramount to making an accurate diagnosis. Situations in which laboratory findings and patient history are not congruent pose a diagnostic dilemma.
Fortune O. Alabi, Christopher O. Alabi, Rafaela G. Basso, Nadia Lakhdar, Adebanke O. Oderinde   +4 more
doaj   +1 more source

Preventing and lessening exacerbations of asthma in school-age children associated with a new term (PLEASANT) : Study protocol for a cluster randomised control trial [PDF]

, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Boote, Jonathan, Bradburn, Mike J., Cooper, Cindy L., Davis, Sarah, Elphick, Heather, Horspool, Michelle J., Julious, Steven A., Norman, Paul, Smithson, W. H., vanStaa, Tjeerd   +9 more
core   +4 more sources

An Anti‐Myd88 Peptide Synergistically Enhances the Anti‐Inflammatory Effects of Extracellular Vesicles from Naïve Umbilical Cord MSC or HEK293F CD24 Overexpressing Cells

Advanced Materials Interfaces, EarlyView.
This study confirms that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) or HEK293F cells overexpressing CD24 have anti‐inflammatory effects in macrophages and monocytes. Further loading either of these EVs with an anti‐Myd88 peptide synergistically enhanced the anti‐inflammatory effects of the EVs.
Burçin İrem Abas, Markus Bergqvist, Lijuan Yu, Yi Wang, Mario Gimona, Kyong‐su Park, Jan Lötvall   +6 more
wiley   +1 more source

Evaluation of Functional Condition of Respiratory Muscles of Patients with a Complicated Bronchial Asthma Pathology and Chronic Obstructive Pulmonary Diseases [PDF]

, 2017
The aim of the research was to study the functional state of respiratory muscles and neuro-respiratory drive in patients with a combined pathology of bronchial asthma and chronic obstructive pulmonary disease.The functional condition of the respiratory ...
Feschenko, Y. (Yuriy), Nazarenko, K. (Ksenia)   +1 more
core   +2 more sources

Advanced Materials in Responsible Electronics: Innovations for Sustainability, Health, and Circularity

Advanced Materials Technologies, EarlyView.
Contemporary electronic devices produce significant waste, harming ecosystems. Innovation in design, consumption, materials, and end‐of‐life management is crucial. This review explores advanced materials for sustainable and responsible electronics, highlighting their potential to reduce environmental and health hazards while improving device ...
Rawan Omar, Jiawei Yang, Tan‐Phat Huynh, Kiran Gulia, Sooyun Caroline Tavolacci, Weiwei Wu, Yan Wang, Hossam Haick   +7 more
wiley   +1 more source