Results 131 to 140 of about 1,415,651 (391)

Development of an Organoautocatalyzed Double σ‐Bond C(sp2)‐N Transamination Metathesis Reaction

Angewandte Chemie, EarlyView.
Organoautocatalyzed transamination metathesis of cyclic tertiary amines is disclosed as a high‐yielding, scalable reaction that proceeds under mild, catalyst‐free conditions. It operates via a multi‐step domino reaction mechanism, where an in situ‐formed pyrrolidinium salt functions as a HBD organoautocatalyst.
Volker Klein, Florian Schuster, Jonas Amthor, Harald Maid, Prabhakar Bijalwan, Fahmi Himo, Stefano Santoro, Svetlana B. Tsogoeva   +7 more
wiley   +2 more sources

Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial [PDF]

, 2011
<b>Background</b> The immune modulating properties of statins may benefit smokers with asthma. We tested the hypothesis that short-term treatment with atorvastatin improves lung function or indices of asthma control in smokers with asthma.<
A McKay, AA Zeki, AA Zeki, AP Greening, C Joukhadar, Charles McSharry, Christopher J Weir, D Cockcroft, D Menzies, DC Cowan, DW McCarey, E Hothersall, E Juniper, E Juniper, E Juniper, EF Juniper, EF Juniper, EF Juniper, EJ Hothersall, Frances Mair, Georgina Braganza, GW Chalmers, I Pavord, Iona Donnelly, J Greenwood, J-H Lee, Jane Lafferty, JEM Tomlinson, JL Wright, K Ito, K Maneechotesuwan, K Samson, KY Chan, L McKinley, Lisa Jolly, M Castro, M Spears, Mark Spears, MD Eisner, N Santanello, N Takeda, N Thomson, Neil C Thomson, PD N'Guessan, R Chaudhuri, Rekha Chaudhuri, S Janda, S Takahashi, S-E Dahlen, SE Alexeeff, Suzanne M Lloyd, V Siroux, X Ou, X Zhang   +53 more
core   +4 more sources

Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma.

New England Journal of Medicine, 2014
BACKGROUND Many patients with severe asthma require regular treatment with oral glucocorticoids despite the use of high-dose inhaled therapy. However, the regular use of systemic glucocorticoids can result in serious and often irreversible adverse ...
E. Bel, S. Wenzel, P. Thompson, C. Prazma, O. Keene, S. Yancey, H. Ortega, I. Pavord   +7 more
semanticscholar   +1 more source

Associations of Historic Residential Pesticide Proximity With Proinflammatory Cytokine Levels in a Patient Population With and Without Chronic Rhinosinusitis (CRS)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Residential proximity to commercial pesticide application has been associated with increased odds of developing chronic rhinosinusitis (CRS) with in vitro studies demonstrating cytotoxic dose‐dependent effects on sinonasal epithelia.
Melodyanne Y. Cheng, Kimberly C. Paul, Jakob L. Fischer, Myles G. Cockburn, Laura K. Thompson, Hong‐Ho Yang, Jeffrey D. Suh, Marilene B. Wang, Jivianne T. Lee   +8 more
wiley   +1 more source

Access to N‐Monofluoromethylated (Thio)Carbamates, Formamides, Alkynamides, and Related Derivatives

Angewandte Chemie, EarlyView.
The first general synthetic access to N‐CH₂F and N‐CHRF carbamates, thiocarbamates, formamides, alkynamides, and related compounds is disclosed. The method involves the direct synthesis of carbamoyl fluoride building blocks from readily available amines, followed by their derivatization. Abstract This work presents the first general synthetic access to
Filip G. Zivkovic, Fritz Bahns, Che‐Ming Hsu, Franziska Schoenebeck   +3 more
wiley   +2 more sources

Eosinophilic inflammation in asthma.

New England Journal of Medicine, 1990
BACKGROUND AND METHODS The importance of eosinophils in the pathogenesis of bronchial asthma is not established. In an attempt to evaluate the role of eosinophilic inflammation in asthma, we compared 10 normal subjects with 43 patients with chronic ...
J. Bousquet, P. Chanez, J. Lacoste, G. Barnéon, Nouchine Ghavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony‐Lafontaine, P. Godard, F. Michel   +10 more
semanticscholar   +1 more source

Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms

ERJ Open Research, 2023
Tessa M. Kole, Simon D. Pouwels, Rene Bults, Marlies E. Ketelaar, Victor Guryev, Lisanne Koll, Huib A.M. Kerstjens, Martijn C. Nawijn, Alen Faiz, Maarten van den Berge   +9 more
doaj   +1 more source

Conducting retrospective impact analysis to inform a medical research charity’s funding strategies: The case of Asthma UK [PDF]

, 2013
© 2013 Hanney et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Amanda Watt, AR Jadad, British Thoracic Society and Scottish Intercollegiate Guidelines Network, British Thoracic Society Scottish Intercollegiate Guidelines Network, Canadian Academy of Medical Sciences, CE Brightling, D Cooksey, E Nason, E Xystrakis, GK Scadding, House of Lords Science and Technology Committee, J Bott, LA Laitinen, LB Bacharier, Leanne Metcalf, LJ Tata, M Buxton, M Buxton, M Thomas, MA Berry, National Institute for Health Research, P Adam, PA Wark, PE Christie, PE Christie, PJ Jose, PM O’Byrne, PV Dicpinigaitis, R Banzi, R Smith, S Hanney, S Hanney, S Hanney, S Hanney, S Saglani, S Walker, S Wooding, SR Durham, Stephen R Hanney, T Pang, Teresa H Jones, TH Lee, UK Evaluation Forum, WJ Oortwijn, WL Oldfield   +44 more
core   +1 more source

MiR‐221‐3p Attenuates IL‐33‐Induced Mast Cell Cytokine Expression by Targeting KIT

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mast cells (MCs) are involved in type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)‐33 stimulation. MiR‐221 is reported to be an important regulator of MCs, and miR‐221‐3p can be expressed in CRSwNP. However, the role of miR‐221‐3p in CRSwNP is unclear. Methods Ethmoid tissues
Ruowu Liu, Jiao Zhou, Jing Zhou, Feng Liu, Yafeng Liu, Juan Meng, Luo Ba, Hengyi Xiao, Shixi Liu, Nan Zhang, Claus Bachert, Jintao Du   +11 more
wiley   +1 more source

The Impact of Poor Housing Conditions on the Health of Asthmatic New Yorkers [PDF]

, 2009
There is an undeniable relationship between poor housing conditions and asthma. Strong evidence suggests that cockroaches are the leading asthma trigger found in the homes of asthmatic New Yorkers.

core