Results 21 to 30 of about 482,292 (251)

Evaluation of Swab-Seq as a scalable, sensitive assay for community surveillance of SARS-CoV-2 infection

Scientific Reports, 2022
The ongoing SARS-CoV-2 pandemic and subsequent demand for viral testing has led to issues in scaling diagnostic lab efforts and in securing basic supplies for collection and processing of samples. This has motivated efforts by the scientific community to
HyunJin Kang, Sheilah Allison, Amber Spangenberg, Tara Carr, Ryan Sprissler, Marilyn Halonen, Darren A. Cusanovich   +6 more
doaj   +1 more source

Feasibility of sustained response through long-term dosing in food allergy immunotherapy

Allergy, Asthma & Clinical Immunology, 2017
Background Clinical trials using oral immunotherapy (OIT) for the treatment of food allergies have shown promising results. We previously demonstrated the feasibility of desensitization for up to 5 food allergens simultaneously through OIT.
Sandra Andorf, Monali Manohar, Tina Dominguez, Whitney Block, Dana Tupa, Rohun A. Kshirsagar, Vanitha Sampath, R. Sharon Chinthrajah, Kari C. Nadeau   +8 more
doaj   +1 more source

The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers

Environmental Health, 2023
Background Exhaled nitric oxide is a marker of airway inflammation. Air pollution induces airway inflammation and oxidative stress. Little is known about the impact of air pollution on exhaled nitric oxide in young infants. Methods The Breathing for Life
Elizabeth Percival, Adam M. Collison, Carla Rebeca da Silva Sena, Ediane De Queiroz Andrade, Patricia De Gouveia Belinelo, Gabriela Martins Costa Gomes, Christopher Oldmeadow, Vanessa E. Murphy, Peter G. Gibson, Wilfried Karmaus, Joerg Mattes   +10 more
doaj   +1 more source

Urinary Eosinophil-derived Neurotoxin Concentrations in Patients with Atopic Dermatitis: A Useful Clinical Marker for Disease Activity

Allergology International, 2007
Background: It has been reported that measurements of eosinophil-derived neurotoxin (EDN) may be useful for identifying eosinophil activities in allergic diseases including atopic dermatitis.
Tomoko Goto, Junichiro Morioka, Hiroaki Inamura, Megumi Yano, Kazumi Kodaira, Yasushi Igarashi, Shyuzo Abe, Motohiro Kurosawa   +7 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Observational long-term follow-up study of rapid food oral immunotherapy with omalizumab

Allergy, Asthma & Clinical Immunology, 2017
Background A number of clinical studies focused on treating a single food allergy through oral immunotherapy (OIT) with adjunctive omalizumab treatment have been published.
Sandra Andorf, Monali Manohar, Tina Dominguez, Whitney Block, Dana Tupa, Rohun A. Kshirsagar, Vanitha Sampath, R. Sharon Chinthrajah, Kari C. Nadeau   +8 more
doaj   +1 more source

Effect of Foot Orthoses on Midfoot Pain and the Volume of Bone Marrow Lesions in the Midfoot: A Randomized Mechanism of Action Study

Arthritis Care &Research, EarlyView.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain, and magnetic resonance imaging–confirmed midfoot BMLs ...
Jill Halstead, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond   +4 more
wiley   +1 more source

Fish oil and vitamin D in pregnancy for the prevention of early childhood asthma: study protocol for two double-blinded, randomised controlled trials

BMJ Open
Introduction Previous randomised controlled trials (RCTs) have indicated a protective role of pregnancy supplementation with fish oil and high-dose vitamin D, respectively, on offspring asthma, infections and several other disorders in early childhood ...
Klaus Bønnelykke, Jakob Stokholm, Rebecca Vinding, Bo Chawes, Julie Nyholm Kyvsgaard, Ulrik Ralfkiaer, Marianne Mikkelsen, Nicklas Brustad, Sarah Brandt, Nilo Vahman   +9 more
doaj   +1 more source

Temporal Trends and Short‐ and Long‐Term Mortality of People With Acute Myocardial Infarction and Rheumatoid Arthritis: A Nationwide Cohort Study

Arthritis Care &Research, EarlyView.
Objective We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analyzed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalized with AMI between 2005 and 2019 from the Myocardial Ischaemia ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A. Mamas   +8 more
wiley   +1 more source

Microbiome and asthma

Asthma Research and Practice, 2018
The mucosal immune system is in constant communication with the vast diversity of microbes present on body surfaces. The discovery of novel molecular mechanisms, which mediate host-microbe communication, have highlighted the important roles played by ...
Milena Sokolowska, Remo Frei, Nonhlanhla Lunjani, Cezmi A. Akdis, Liam O’Mahony   +4 more
doaj   +1 more source