Results 41 to 50 of about 1,522,848 (395)

Efficacy and Safety of Dupilumab in Glucocorticoid‐Dependent Severe Asthma

New England Journal of Medicine, 2018
BACKGROUND Dupilumab is a fully human anti–interleukin‐4 receptor α monoclonal antibody that blocks both interleukin‐4 and interleukin‐13 signaling. Its effectiveness in reducing oral glucocorticoid use in patients with severe asthma while maintaining ...
K. Rabe, Parameswaran Nair, G. Brusselle, J. Maspero, M. Castro, L. Sher, Hongjie Zhu, J. Hamilton, B. Swanson, A. Khan, J. Chao, H. Staudinger, G. Pirozzi, C. Antoni, N. Amin, M. Ruddy, B. Akinlade, N. Graham, N. Stahl, G. Yancopoulos, A. Teper   +20 more
semanticscholar   +1 more source

MyAirCoach: The use of home-monitoring and mHealth systems to predict deterioration in asthma control and the occurrence of asthma exacerbations; Study protocol of an observational study [PDF]

, 2016
© Published by the BMJ Publishing Group Limited. Introduction Asthma is a variable lung condition whereby patients experience periods of controlled and uncontrolled asthma symptoms.
Bonini, Matteo, Chung, Kian Fan, Fowler, Stephen, Honkoop, Persijn J., Meah, Sally, Simpson, Andrew, Snoeck-Stroband, Jiska B., Sont, Jacob K., Usmani, Omar S.   +8 more
core   +4 more sources

Feasibility of sustained response through long-term dosing in food allergy immunotherapy

Allergy, Asthma & Clinical Immunology, 2017
Background Clinical trials using oral immunotherapy (OIT) for the treatment of food allergies have shown promising results. We previously demonstrated the feasibility of desensitization for up to 5 food allergens simultaneously through OIT.
Sandra Andorf, Monali Manohar, Tina Dominguez, Whitney Block, Dana Tupa, Rohun A. Kshirsagar, Vanitha Sampath, R. Sharon Chinthrajah, Kari C. Nadeau   +8 more
doaj   +1 more source

High cytomegalovirus serology and subsequent COPD-related mortality: a longitudinal study

ERJ Open Research, 2020
Background Positive serology for cytomegalovirus (CMV) has been associated with all-cause mortality risk but its role in COPD mortality is unknown. The objective of the present study was to assess the relationship between CMV serology and COPD mortality.
Raffaella Nenna, Jing Zhai, Samuel E. Packard, Amber Spangenberg, Duane L. Sherrill, Fernando D. Martinez, Marilyn Halonen, Stefano Guerra   +7 more
doaj   +1 more source

Cytomegalovirus serology in young to mid‐adult life and decline of lung function

The Clinical Respiratory Journal, 2023
Introduction Cytomegalovirus (CMV) seropositivity has been recently linked to severity and progression of asthma, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). To date, no longitudinal study has addressed the relation of CMV serology
Raffaella Nenna, Jing Zhai, Amber Spangenberg, Duane L. Sherrill, Fernando D. Martinez, Marilyn Halonen, Stefano Guerra   +6 more
doaj   +1 more source

The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers

Environmental Health, 2023
Background Exhaled nitric oxide is a marker of airway inflammation. Air pollution induces airway inflammation and oxidative stress. Little is known about the impact of air pollution on exhaled nitric oxide in young infants. Methods The Breathing for Life
Elizabeth Percival, Adam M. Collison, Carla Rebeca da Silva Sena, Ediane De Queiroz Andrade, Patricia De Gouveia Belinelo, Gabriela Martins Costa Gomes, Christopher Oldmeadow, Vanessa E. Murphy, Peter G. Gibson, Wilfried Karmaus, Joerg Mattes   +10 more
doaj   +1 more source

Increasing prevalence of asthma diagnosis and symptoms in children is confined to mild symptoms [PDF]

, 2001
BACKGROUND: The prevalence of childhood asthma is increasing but few studies have investigated trends in asthma severity. We investigated trends in asthma diagnosis and symptom morbidity between an eight year time period in a paired prevalence study.
Billings, C., Das, C., Duggan, R., Ng Man Kwong, G., Powell, C.V.E., Primhak, R.A., Proctor, A., Whyte, M.K.B.   +7 more
core   +2 more sources

Urinary Eosinophil-derived Neurotoxin Concentrations in Patients with Atopic Dermatitis: A Useful Clinical Marker for Disease Activity

Allergology International, 2007
Background: It has been reported that measurements of eosinophil-derived neurotoxin (EDN) may be useful for identifying eosinophil activities in allergic diseases including atopic dermatitis.
Tomoko Goto, Junichiro Morioka, Hiroaki Inamura, Megumi Yano, Kazumi Kodaira, Yasushi Igarashi, Shyuzo Abe, Motohiro Kurosawa   +7 more
doaj   +1 more source

Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

European Respiratory Journal, 2019
This document provides clinical recommendations for the management of severe asthma. Comprehensive evidence syntheses, including meta-analyses, were performed to summarise all available evidence relevant to the European Respiratory Society/American ...
F. Holguin, J. Cardet, K. Chung, S. Diver, D. S. Ferreira, A. Fitzpatrick, M. Gaga, Liz Kellermeyer, S. Khurana, Shandra L. Knight, V. McDonald, R. Morgan, V. Ortega, D. Rigau, P. Subbarao, T. Tonia, I. Adcock, E. Bleecker, C. Brightling, L. Boulet, M. Cabana, M. Castro, P. Chanez, A. Custovic, R. Djukanović, U. Frey, B. Frankemölle, P. Gibson, D. Hamerlijnck, N. Jarjour, S. Konno, Huahao Shen, C. Vitary, A. Bush   +33 more
semanticscholar   +1 more source

Chicago Asthma Epidemic: The Status of Asthma in Chicago [PDF]

, 2007
Chicago is known for many things, our great food and architecture. Unfortunately, we are also known for being an epi-center for asthma. We lead the Nation in asthma deaths, emergency room visits and hospitalizations.

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