Results 61 to 70 of about 1,451,332 (395)

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Medication Use in Multiple Sclerosis: A Population‐Based Comparison With the General Danish Population

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the overall use of prescription medications among individuals with multiple sclerosis compared to the general population, with a focus on treatments beyond disease‐modifying therapies. Methods We conducted a nationwide, registry‐based study in Denmark.
Josefine Windfeld‐Mathiasen, Henrik Horwitz, Ida M. Heerfordt, Elisabeth Framke, Melinda Magyari   +4 more
wiley   +1 more source

Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats

Advanced Biology, EarlyView.
Fecal microbiota transplantation (FMT) alleviates lung and intestinal injury in lipopolysaccharide (LPS)‐induced acute respiratory distress syndrome (ARDS) in rats. This study demonstrates that FMT restores the balance between Th17 and Treg cells, inhibits the JAK/STAT pathway, and modulates cytokine levels, reducing inflammation and lung damage. These
Dongwei Zhang, Biying Dong, Jie Chen, Zhenqiang Zhang, Weitong Zeng, Longxiong Liao, Xia Xiong, Xuejun Qin, Xianming Fan   +8 more
wiley   +1 more source

Microbiome and asthma

Asthma Research and Practice, 2018
The mucosal immune system is in constant communication with the vast diversity of microbes present on body surfaces. The discovery of novel molecular mechanisms, which mediate host-microbe communication, have highlighted the important roles played by ...
Milena Sokolowska, Remo Frei, Nonhlanhla Lunjani, Cezmi A. Akdis, Liam O’Mahony   +4 more
doaj   +1 more source

Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19

Nature Communications, 2023
Rhinoviruses and allergens, such as house dust mite are major agents responsible for asthma exacerbations. The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely ...
Urszula Radzikowska, Andrzej Eljaszewicz, Ge Tan, Nino Stocker, Anja Heider, Patrick Westermann, Silvio Steiner, Anita Dreher, Paulina Wawrzyniak, Beate Rückert, Juan Rodriguez-Coira, Damir Zhakparov, Mengting Huang, Bogdan Jakiela, Marek Sanak, Marcin Moniuszko, Liam O’Mahony, Marek Jutel, Tatiana Kebadze, David J. Jackson, Michael R. Edwards, Volker Thiel, Sebastian L. Johnston, Cezmi A. Akdis, Milena Sokolowska   +24 more
doaj   +1 more source

The effect of early child care attendance on childhood asthma and wheezing: A meta-analysis. [PDF]

, 2018
ObjectiveResearch evidence offers mixed results regarding the relationship between early child care attendance and childhood asthma and wheezing. A meta-analysis was conducted to synthesize the current research evidence of the association between early ...
Alkon, Abbey, Bekmezian, Arpi, Cabana, Michael D, Celedon, Juan, Coffman, Janet, Collier, Tina, Cruz, Eddie, Swartz, Alicia, Young, Chelsea Anne   +8 more
core   +2 more sources

Maturation of the gut microbiome and risk of asthma in childhood

Nature Communications, 2018
The composition of the human gut microbiome matures within the first years of life. It has been hypothesized that microbial compositions in this period can cause immune dysregulations and potentially cause asthma.
J. Stokholm, M. Blaser, J. Thorsen, M. Rasmussen, Johannes Waage, R. Vinding, A. Schoos, Asja Kunøe, N. R. Fink, B. Chawes, K. Bønnelykke, A. Brejnrod, Martin Steen Mortensen, W. Al-Soud, S. Sørensen, H. Bisgaard   +15 more
semanticscholar   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk

Nature Communications, 2020
Genetic variants in KIF3A are associated with atopic dermatitis (AD). Here, the authors identify two AD-risk alleles that show high methylation resulting in lower KIF3A expression.
Mariana L. Stevens, Zhonghua Zhang, Elisabet Johansson, Samriddha Ray, Amrita Jagpal, Brandy P. Ruff, Arjun Kothari, Hua He, Lisa J. Martin, Hong Ji, Kathryn Wikenheiser-Brokamp, Matthew T. Weirauch, Dorothy M. Supp, Jocelyn M. Biagini Myers, Gurjit K. Khurana Hershey   +14 more
doaj   +1 more source

Deaths certified as asthma and use of medical services: A national case-control study [PDF]

, 2005
This is an open access publication. The official published version can be accessed from the link below.Background: Studies have linked asthma death to either increased or decreased use of medical services.
Anderson, H, Ayres, J, Bland, J, Butland, B, Harrison, B, on, b, Peckitt, C, Sturdy, P, Victor, C   +8 more
core   +2 more sources