Results 81 to 90 of about 1,230,724 (345)

Evaluation of Functional Condition of Respiratory Muscles of Patients with a Complicated Bronchial Asthma Pathology and Chronic Obstructive Pulmonary Diseases [PDF]

, 2017
The aim of the research was to study the functional state of respiratory muscles and neuro-respiratory drive in patients with a combined pathology of bronchial asthma and chronic obstructive pulmonary disease.The functional condition of the respiratory ...
Feschenko, Y. (Yuriy), Nazarenko, K. (Ksenia)   +1 more
core   +2 more sources

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Environmental public health tracking of childhood asthma using California health interview survey, traffic, and outdoor air pollution data. [PDF]

, 2008
BackgroundDespite extensive evidence that air pollution affects childhood asthma, state-level and national-level tracking of asthma outcomes in relation to air pollution is limited.ObjectivesOur goals were to evaluate the feasibility of linking the 2001 ...
Balmes, John, English, Paul, Meng, Ying-Ying, Ritz, Beate, Rull, Rudolph P, Wilhelm, Michelle   +5 more
core  

Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition

BMC Biology
Background T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function.
Jana Koch, Alessandra Ruggia, Carina Beha, Irina Wipf, Damir Zhakparov, Patrick Westermann, Svenja Schmelzer, Anja Heider, Klemens Fröhlich, Katja Baerenfaller   +9 more
doaj   +1 more source

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

Advanced Science, EarlyView.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita   +18 more
wiley   +1 more source

Distinguishing Asthma Phenotypes Using Machine Learning Approaches. [PDF]

, 2015
Asthma is not a single disease, but an umbrella term for a number of distinct diseases, each of which are caused by a distinct underlying pathophysiological mechanism. These discrete disease entities are often labelled as asthma endotypes.
A Custovic, A Custovic, A Fraser, A Høst, A Pickles, A Simpson, A Wijga, Adnan Custovic, AJ Lowe, AV Berg, B Clarisse, BD Spycher, BD Spycher, BD Spycher, BG Toelle, BL Jones, BL Jones, C-M Chen, CA Figueiredo, CE Kuehni, CJ Lodge, CL Storr, D Barber, D Belgrave, D Caudri, D Nagin, DA Linzer, DC Belgrave, DC Belgrave, DCM Belgrave, DCM Belgrave, F Kauffmann, F Kauffmann, FD Martinez, FL Garden, FP Perera, G Bochenek, G Weinmayr, GB Marks, GP Anderson, J Hagenaars, J Henderson, J Lotvall, J Magidson, J Sunyer, J Winn, JA Smith, JK Vermunt, K Burnham, KE Wonderen Van, KL Nylund, L García-Marcos Álvarez, L Hunt, L Lowe, L Panico, LA Lowe, M Depner, M Herr, M Scott, Magnus Rattray, Mattia Prosperi, MJ Ege, ML Barreto, MM Hagendorens, MW Pijnenburg, N Lazic, NC Nicolaou, NG Papadopoulos, OE Savenije, P Burney, P Haldar, P Rzehak, P Rzehak, PD Sly, Q Chen, Q Vuong, Rebecca Howard, RJP Valk van der, RL Bergmann, RL Miller, RO Crapo, RT Stein, S American Thoracic, S Havstad, S Mihrshahi, S Rabe-Hesketh, S Stanojevic, SE Wenzel, SK Weiland, ST Lanza, ST Lanza, T Jung, T Minka, The European Community Respiratory Health Survey, V Siroux, WC Moore, X Robin, Y Lo   +97 more
core   +2 more sources

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Road-traffic pollution and asthma – using modelled exposure assessment for routine public health surveillance [PDF]

, 2004
Asthma is a common disease and appears to be increasing in prevalence. There is evidence linking air pollution, including that from road-traffic, with asthma. Road traffic is also on the increase.
Daly, M., Ferguson, E.C., Maheswaran, R.
core   +3 more sources

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]

, 2016
Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L., Coltherd, J. C., Harnett, M. M., Harnett, W., Lawrie, R. E., Rodgers, D. T., Suckling, C. J.   +6 more
core   +1 more source