Results 171 to 180 of about 613,926 (308)

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

British Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop, Gertjan J. A. Driessen, Adam F. Cohen, Matthijs D. Kruizinga   +3 more
wiley   +1 more source

Effects of ICS + LABA Combination Therapy on Asthma Control: An Observational Study in Real-World Settings. [PDF]

Ther Clin Risk Manag
Han P, Wang L.
europepmc   +1 more source

Housing Warmth/Coolness and Quietness Correlate With Whole‐Brain Fractional Anisotropy in Healthy Adults

Brain Health, EarlyView.
ABSTRACT Introduction Residential environments have been linked to brain structure, particularly in children, older adults, and clinical populations. However, little is known about how different dimensions of the housing environment relate to brain white matter microstructure in healthy adults, or whether specific environmental factors show stronger ...
Keisuke Kokubun, Kiyotaka Nemoto, Toshiharu Ikaga, Yoshinori Yamakawa   +3 more
wiley   +1 more source

No Improvement of Asthma Control Despite Changes in Pharmacological Treatment Patterns - 17 Years Follow Up. [PDF]

J Asthma Allergy
Ahlroth Pind C, Ställberg B, Lisspers K, Sundh J, Kisiel MA, Sandelowsky H, Nager A, Hasselgren M, Montgomery S, Giezeman M, Eliason G, Janson C.   +11 more
europepmc   +1 more source

Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis

Chemistry – A European Journal, EarlyView.
We demonstrate a sustainable strategy for pharmaceutical manufacturing by combining hydrogen, heterogeneous catalysis, and continuous flow synthesis. The development of novel catalysts and their application in a multi‐step synthesis of donepezil enabled a highly productive process with no intermediate purification.
Shū Kobayashi, Haruro Ishitani
wiley   +1 more source

Dupilumab Reduces Asthma Disease Burden and Recurrent SCS Use in Patients with CRSwNP and Coexisting Asthma

Journal of Asthma and Allergy
Mark Gurnell,1,2 Amr Radwan,3 Claus Bachert,4– 6 Njira Lugogo,7 Seong H Cho,8 Scott Nash,9 Haixin Zhang,9 Asif H Khan,10 Juby A Jacob-Nara,11 Paul J Rowe,11 Yamo Deniz9 1Department of Medicine, Wellcome–MRC Institute of Metabolic Science, University of ...
Gurnell M, Radwan A, Bachert C, Lugogo N, Cho SH, Nash S, Zhang H, Khan AH, Jacob-Nara JA, Rowe PJ, Deniz Y   +10 more
doaj  

Towards improved asthma control in children by non-invasive home monitoring. [PDF]

Sci Rep
Gijsen CEW, Lucas J, Muris JWM, van Horck MWP, Sieben AEP, Dompeling E.   +5 more
europepmc   +1 more source

Association of Neurodevelopmental Disorders and Congenital Anomalies With Prenatal Multiple Sclerosis Treatment—Real‐World Historical Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
There is a paucity of data regarding the effects of prenatal disease‐modifying therapies (DMTs) for multiple sclerosis (MS), on congenital anomalies in the offspring. Moreover, data on the association with neurodevelopmental disorders are lacking. This is an historical cohort study, within the Israeli Clalit Health Services database (2005–2024) that ...
Bar Rosh, Ofek Levi, Nili Stein, Amir Yahav, Naomi Gronich   +4 more
wiley   +1 more source

Wildfire smoke and pediatric asthma control in the Northeastern United States: a cross-sectional study. [PDF]

Environ Health
Maassel AK, Brochu P, Harder VS, Ricketts TH, Teach SJ, Robinson KJ.   +5 more
europepmc   +1 more source

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, EarlyView.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source