Results 251 to 260 of about 283,599 (345)

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Rotenone targets midbrain astrocytes to produce glial dysfunction-mediated dopaminergic neurodegeneration. [PDF]

Acta Neuropathol Commun
Miyazaki I, Isooka N, Kikuoka R, Imafuku F, Masai K, Tomimoto K, Sakaguchi M, Sogawa C, Sogawa N, Kitamura Y, Asanuma M.   +10 more
europepmc   +1 more source

Heterogeneity of Astrocytes: From Development to Injury – Single Cell Gene Expression

, 2013
Vendula Rusnakova, Pavel Honsa, Dávid Džamba, Anders Ståhlberg, Mikael Kubista, Miroslava Anděrová   +5 more
openalex   +2 more sources

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Small molecule-mediated rapid generation of functional human astrocytes: unveiling AKT1-STAT1/3 signaling in astrocyte development. [PDF]

Stem Cell Res Ther
Garg P, Lenk K, Sundaram SM.
europepmc   +1 more source

Ciliary neurotrophic factor activation of astrocytes mediates neuronal damage via the IL‑6/IL‑6R pathway

Hongtao Wang, Sitong Lu, Zhihui Xia, Tao Xu, Weiyan Zou, Meiqun Sun   +5 more
openalex   +2 more sources

Identification of diverse astrocyte populations and their malignant analogs

Nature Neuroscience, 2017
Chia-Ching John Lin, Kwanha Yu, Asante Hatcher, Teng-Wei Huang, Hyun Kyoung Lee, Jeffrey C. Carlson, Matthew C. Weston, Fengju Chen, Yiqun Zhang, Wenyi Zhu, C. Mohila, N. Ahmed, Akash J. Patel, Benjamin R. Arenkiel, J. Noebels, C. Creighton, B. Deneen   +16 more
semanticscholar   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Modeling neuron-astrocyte interactions in neural networks using distributed simulation. [PDF]

PLoS Comput Biol
Jiang HJ, Aćimović J, Manninen T, Ahokainen I, Stapmanns J, Lehtimäki M, Diesmann M, van Albada SJ, Plesser HE, Linne ML.   +9 more
europepmc   +1 more source

Parallel astrocyte calcium signaling modulates olfactory bulb responses

, 2020
Kevin Ung, Burak Tepe, Brandon Pekarek, Benjamin R. Arenkiel, Benjamin Deneen   +4 more
openalex   +2 more sources