Results 301 to 310 of about 283,599 (345)

NDRG2 upregulation induces astrocytic apoptosis via AKT inhibition and FoxO3a-Puma activation in depression. [PDF]

Commun Biol
Wang Z, Yang J, Zhang H, Ke D, Zhang L, Liu Y, Lai Y, Zhang Y, Qin X, Yang J, Kang M, Yang W, Wang X, Zeng J, Liu R.   +14 more
europepmc   +1 more source

Methamphetamine Inhibits the Glucose Uptake by Human Neurons and Astrocytes: Stabilization by Acetyl-L-Carnitine

, 2011
P. M. Abdul Muneer, Saleena Alikunju, Adam M. Szlachetka, James Haorah   +3 more
openalex   +2 more sources

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Advanced Science, EarlyView.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Xu, Hongxi Wu   +8 more
wiley   +1 more source

Impact of isoflurane anesthesia on astrocyte connexin 30 expression in adult rats and its possible implications for postoperative neurocognitive disorder. [PDF]

Eur J Med Res
Li MY, Zhang XX, Sun XL, Wang ZY, Li J, Zhang XN.   +5 more
europepmc   +1 more source

Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

Advanced Science, EarlyView.
Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao, Zhonghua Xiong, Wenting Su, Jiahui Deng, Bin Zhai, Gaizhi Zhu, Min Zhang, Qi Zeng, Jinming Qiu, Ziqing Bian, He Xiao, Guoming Luan, Renxi Wang   +12 more
wiley   +1 more source

Carbon Monoxide Nanomodulator Reverses Ischemia‐Reperfusion Injury in Stroke: A Novel Dual‐Channel Therapy Mode of Co‐driving Neuroprotection and Neurogenesis

Advanced Science, EarlyView.
This work develops a biomimetic and reactive oxygen species‐activated carbon monoxide (CO) nanogenerator to penetrate blood‐brain barrier, arrive in stroke‐affected regions, and release CO in a controlled manner for an innovative dual‐channel therapy strategy via co‐driving neuroprotection and neurogenesis.
Xuegang Niu, Bin Gao, Hongyi Huang, Zesheng Li, Yibin Zhang, Quanlei Liu, Chao Zhang, Yang Dai, Jinkun Xu, Mingshan Liu, Yuanyuan Zhang, Yihe Wang, Penghu Wei, Yuanxiang Lin, Yongzhi Shan, Yumin Luo, Dezhi Kang, Guoguang Zhao   +17 more
wiley   +1 more source

Cholesterol-driven pathological astrocytic responses in diabetes-associated cognitive impairment through astrocytic SCAP accumulation and NF-κB-C3 signaling modulation. [PDF]

Exp Mol Med
Niu T, Wang S, Zhang H, Zhu W, Liu K, Zhou X, Sun R, Niu D, Yuan Y.   +8 more
europepmc   +1 more source

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

Advanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li   +8 more
wiley   +1 more source

Upregulated astrocytic HDAC7 induces depression-like disorders via deacetylating PINK1 and inhibiting mitophagy. [PDF]

J Neuroinflammation
Yue RZ, Guo X, Li CJ, Wu LJ, Liu YT, Hu J, Yan BK, Lin HT, Tang YL, Yan WM, Xiao S, Hao Y, Ye J.   +12 more
europepmc   +1 more source

Disordered Glass Nanowire Substrates Produce in Vivo‐Like Astrocyte Morphology Revealed by Low‐Coherence Holotomography

Advanced Science, EarlyView.
Low‐coherence holotomography reveals that disordered nanowire substrates guide astrocyte morphology toward branched, in vivo–like star‐shaped morphology, emphasizing the role of biophysical cues in shaping neural cell behavior. The developed nanostructured platform offers a new route to study astrocytes for neurobiology studies. Abstract Astrocytes are
Pooja Anantha, Anoushka Gupta, Joo Ho Kim, Emanuela Saracino, Piyush Raj, Ivano Lucarini, Swati Tanwar, Jessica Chen, Luo Gu, Jay Agrawal, Annalisa Convertino, Ishan Barman   +11 more
wiley   +1 more source