Results 311 to 320 of about 176,729 (360)

5‐Aza combined with VPA reprograms human T lineage acute leukemia Jurkat cells into B‐cell‐like cells by epigenetic activation of PAX5

Biotechnology Progress, EarlyView.
Abstract Epigenetic regulation plays an important role in cell fate reprogramming. Here, we found that inhibitors of epigenetic modifiers, including VPA, TSA, and 5‐Aza‐2'‐deoxycytidine, can induce phenotypic transformation from Jurkat cells into B‐cell‐like cells. When Jurkat cells were treated with 5‐Aza combined with VPA, B cell and stem cell marker
Wenjin Xi, Guoxu Zheng, Xu Chen, Baile Zuo, Wei Wang, Yufang Li, Chunmei Zhang, Jie Chu, Xiuli Mu, Weihong Wen, Tao Wang, An‐Gang Yang   +11 more
wiley   +1 more source

A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease. [PDF]

Heliyon
Gong Z, Guo D, Lin Y, Liu Z, Lv M, Liu X, Yao Y, Wang S, Wang Y, Wang Z.   +9 more
europepmc   +1 more source

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source

Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner. [PDF]

Genome Biol
Maddhesiya P, Lepko T, Steiner-Mezzardi A, Schneider J, Schwarz V, Merl-Pham J, Berger F, Hauck SM, Ronfani L, Bianchi M, Simon T, Krontira A, Masserdotti G, Götz M, Ninkovic J.   +14 more
europepmc   +1 more source

Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages

Cancer Communications, EarlyView.
Abstract Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM.
Rongrong Zhao, Ziwen Pan, Jiawei Qiu, Boyan Li, Yanhua Qi, Zijie Gao, Wei Qiu, Weijie Tang, Xiaofan Guo, Lin Deng, Gang Li, Hao Xue   +11 more
wiley   +1 more source

Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury. [PDF]

J Neuroinflammation
Quan L, Uyeda A, Manabe I, Muramatsu R.
europepmc   +1 more source

Production of hemopoietic colony-stimulating factors by astrocytes.

, 1990
Ursula Malipiero, Karl Frei, A. Fontana
openalex   +1 more source

Astrocyte-secreted factors modulate synaptic protein synthesis as revealed by puromycin labeling of isolated synaptosomes. [PDF]

Front Mol Neurosci
de la Cruz-Gambra A, Baleriola J.
europepmc   +1 more source

Astroglia's role in synchronized spontaneous neuronal activity: from physiology to pathology. [PDF]

Front Cell Neurosci
Ammothumkandy A, Cayce A, Shariq M, Bonaguidi MA.   +3 more
europepmc   +1 more source

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

Chemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb, Morkoss Fakhry, Ali K. Albuhadily, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha   +5 more
wiley   +1 more source