Results 311 to 320 of about 283,599 (345)

Histone Deacetylases in Neurodegenerative Diseases and Their Potential Role as Therapeutic Targets: Shedding Light on Astrocytes. [PDF]

Pharmaceuticals (Basel)
Pinheiro PSM, Diniz LP, Franco LS, Siqueira M, Gomes FCA.   +4 more
europepmc   +1 more source

Astrocyte reactivity associates with tau phosphorylation and neurodegeneration before detectable amyloid‐β pathology

Pampa Saha, Guilherme Povala, Pâmela C.L. Ferreira, Lívia Amaral, Sarah Abbas, Firoza Z Lussier, Matheus Scarpatto Rodrigues, Markley Oliveira, Nesrine Rahmouni, Cécile Tissot, Carolina Soares, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Chang‐Hyung Hong, Hyun Woong Roh, Helmet T. Karim, Andréa Lessa Benedet, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Thomas K. Karikari, Sang Joon Kim, Bruna Bellaver, Tharick A. Pascoal, Pedro Rosa‐Neto   +25 more
openalex   +1 more source

Integrated ERK‐PKA‐YAP/TAZ‐SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification

Advanced Science, EarlyView.
This study shows that ERK/PKA upregulation in mammalian cortical radial glia (RGs) sustains neurogenesis and suppresses gliogenesis. YAP/TAZ activation promotes ependymal cell formation, while enhanced SHH‐SMO signaling induces astrocyte, oligodendrocytes, and olfactory bulb interneuron generation.
Zhuangzhi Zhang, Zhejun Xu, Tongye Fu, Jialin Li, Feihong Yang, Chuannan Yang, Wenhui Zheng, Zizhuo Sha, Yanjing Gao, Mengge Sun, Zhenmeiyu Li, Jing Ding, Xiaosu Li, Zhengang Yang   +13 more
wiley   +1 more source

Microglia-astrocyte crosstalk following ischemic stroke. [PDF]

Mol Brain
Yang S, Chen Y, Tang J, Cui Y, Wei W, Hao Z, Xiao Z, Pan Y, Tian Q, Xin W, Li M.   +10 more
europepmc   +1 more source

Neuroprotection and Axonal Regeneration via ECM‐Mimetic Nanofibers Incorporating Metal–Phenolic Network Nanoparticles Toward Spinal Cord Injury Repair

Advanced Science, EarlyView.
Metal–phenolic network (MPN) nanoparticles with neuroprotective functions are integrated into decellularized extracellular matrix (dECM) to obtain biomimetic composite fibrous scaffold MPN@dECM NFs by electrospinning, which protects spared neurons from secondary degeneration by suppressing excitotoxicity and inflammation, and promotes directional ...
Shu Chen, Bixue Wang, Qiya Zhang, Changsheng Liu, Xi Chen   +4 more
wiley   +1 more source

Ptbp1 knockdown induces conversion of rat spinal cord astrocytes into neuron like cells. [PDF]

Sci Rep
Hu X, Han S, Li Z, Li Y, Gao J.
europepmc   +1 more source

NIR‐Triggered Upconversion‐Perovskite Heterostructures for Non‐Genetic, Implant‐Free Optoelectronic Neuromodulation

Advanced Science, EarlyView.
The Single‐Nanostructured Optoelectronic Vehicle for neuromodulation Activation (SNOVA) establishes a paradigm for non‐genetic, implant‐free neuromodulation. By integrating NIR‐excitable UCNPs with broadband‐absorbing perovskite QDs, SNOVA efficiently converts deeply penetrating light into localized electric fields that modulate neuronal ion dynamics ...
Luyue Jiang, Chenguang Ma, Yiping Zhao, Jiazhi Li, Gen Li, Shuang Jin, Haoyang Su, Ye Tian, Yingkang Yang, Yunfu Luo, Lei Huang, Peijie Chen, Yiming Gao, Yi Wei, Yike Xiang, Lunming Qin, Kaihuan Zhang, Yifei Ye, Pengyi Tang, Liuyang Sun   +19 more
wiley   +1 more source

Astrocytes in Fear Memory Processing: Molecular Mechanisms Across the Amygdala-Hippocampus-Prefrontal Cortex Network. [PDF]

Cells
Kim YR, Lee M, Kim MS.
europepmc   +1 more source

USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study reveals that the deubiquitinase USP11 stabilizes PGAM5, triggering neurotoxic astrocyte transformation after intracerebral hemorrhage. PGAM5 promotes mPTP opening and Drp1 dephosphorylation, synergistically amplifying mtDNA leakage into the cytosol and leading to cGAS–STING hyperactivation.
Jiaqing He, Zijuan Qin, Yaning Cai, Haixiao Liu, Tinghao Wang, Qing Hu, Yanni Xu, Pan Yang, Xun Wu, Yan Qu, Wei Guo   +10 more
wiley   +1 more source

TSPO contributes to neuropathology and cognitive deficits in Alzheimer's disease. [PDF]

J Neuroinflammation
Ceyzériat K, Badina AM, Abjean L, Meyer L, Bouteldja F, Balkota M, Amossé Q, Prudhomme O, Middleton RJ, Liu GJ, Banati RB, Zilli T, Lathuiliere A, Owen D, Maechler P, Garibotto V, Tsartsalis S, Millet P, Tournier BB.   +18 more
europepmc   +1 more source