Results 91 to 100 of about 185,860 (239)

Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. [PDF]

open access: yes, 2018
Reactive astrocytes influence post-injury recovery, repair, and pathogenesis of the mammalian CNS. Much of the regulation of astrocyte reactivity, however, remains to be understood.
Carolino, Krislyn I   +13 more
core   +2 more sources

Magnetic‐Driven Torque‐Induced Electrical Stimulation for Millisecond‐Scale Wireless Neuromodulation

open access: yesAdvanced Healthcare Materials, EarlyView.
MagTIES is a wireless neuromodulation technique with millisecond precision. It employs magnetic‐driven torque from magnetite nanodiscs to activate piezoelectric nanoparticles, enabling precise temporal control of neuronal activity and brain oscillations using weak, low‐frequency magnetic fields.
Chao‐Chun Cheng   +5 more
wiley   +1 more source

Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner. [PDF]

open access: yes, 2017
Prions are infectious agents that cause neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD). The absence of a human cell culture model that replicates human prions has hampered prion disease research for decades.
Alibhai, James   +9 more
core   +1 more source

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

open access: yesAdvanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum   +28 more
wiley   +1 more source

Pathological phenotypes of astrocytes in Alzheimer’s disease

open access: yesExperimental and Molecular Medicine
Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta ...
Junhyung Kim   +3 more
doaj   +1 more source

Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis

open access: yesAdvanced Materials, Volume 37, Issue 13, April 2, 2025.
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou   +10 more
wiley   +1 more source

Pro-inflammatory Effect of Downregulated CD73 Expression in EAE Astrocytes

open access: yesFrontiers in Cellular Neuroscience, 2019
CD73, an ectonucleotidase, participates in the regulation of immune responses by controlling the conversion of extracellular AMP to adenosine. In this study, we investigated whether any type of brain cells, especially neuroglia cells, exhibit altered ...
Shumin Zhou   +5 more
doaj   +1 more source

Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

open access: yesAdvanced Materials Interfaces, EarlyView.
This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania   +2 more
wiley   +1 more source

Automated Transcranial Photobiomodulation in Healthy Rats: Effects on Working Memory and Brain Markers

open access: yesAdvanced Therapeutics, EarlyView.
Transcranial photobiomodulation (PBM) enhances spatial working memory in healthy rats under both continuous and alternating stimulation protocols. At the neural level, PBM modulates cytochrome c oxidase activity, increases prefrontal and hippocampal synaptic markers, and induces region‐specific c‐Fos expression. These effects suggest improved cognitive
Candela Zorzo   +6 more
wiley   +1 more source

Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease

open access: yesJournal of Pharmacological Sciences, 2020
The pathophysiological roles of astrocytes in the reactive state are thought to have important significance in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD).
Moonseok Choi   +3 more
doaj  

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