Results 131 to 140 of about 9,888 (286)

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Exploring student estimates of astronomical scales: Impact of question formulation and visualization

Physical Review Physics Education Research
Estimating astronomical scales requires multiple complex mental processes, such as spatial thinking and interpreting large numbers. As such, it is a nontrivial question how these estimates can be most efficiently assessed. There is reason to believe that
Willem Keppens, Mieke De Cock, Hans Van Winckel, Wim Van Dooren, Jan Sermeus   +4 more
doaj   +1 more source

Machine Learning Accelerated Non‐Adiabatic Molecular Dynamics Elucidates Local Polarization Effects on Non‐radiative Recombination in Halide Perovskites

Advanced Science, EarlyView.
This work proposes and constructs the Hefei‐NAMD‐S framework based on machine learning stacked models to investigate the relationship between local polarization and non‐radiative recombination. The results indicate that, compared with A‐site local polarization, B‐site local polarization shows a more evident association with the non‐radiative ...
Bing Yang, Xiaoli Wei, Bo Cai, Yan Yang, Xinghai Zhu, Yi Liu, Junmin Xia, Lihui Liu, Kun Cao, Wei Shen, Pengfei Xia, Shufen Chen, Siyu Chen, Jin Zhao   +13 more
wiley   +1 more source

Unconventional Hysteretic Charge Filling in Moiré‐Reconstructed Helical Trilayer Graphene

Advanced Science, EarlyView.
In helical trilayer graphene, sequential twisting reconstructs the moiré landscape into periodic domains separated by aperiodic boundaries. Longitudinal transport reveals sweep‐direction‐dependent hysteresis, while the Hall response traces this behavior to hysteretic charge filling at the aperiodic boundaries.
Hangyeol Park, Junhyeok Oh, Rasoul Ghadimi, Chiranjit Mondal, Yungi Jeong, Won Beom Choi, Kenji Watanabe, Takashi Taniguchi, Bohm‐Jung Yang, Joonho Jang   +9 more
wiley   +1 more source

Machine‐Learning‐Enhanced Printed Vertical Magnetoresistive Sensors for Transparent, Flexible, Multimodal Interactive Magnetoelectronics

Advanced Science, EarlyView.
This study presents printed magnetoresistive sensors with a vertically aligned architecture that enables high optical transparency and mechanical flexibility. By integrating deep learning for the analysis of complex spatiotemporal signal patterns, the system further achieves intelligent multimodal interaction capabilities.
Rui Xu, Guannan Mu, Oleksandr V. Pylypovskyi, Qihao Zhang, Rico Illing, René Hübner, Ran He, Andreas Knüpfer, Sebastian Lehmann, Olha Bezsmertna, Kornelius Nielsch, Denys Makarov   +11 more
wiley   +1 more source

A Multiple-detection-heads Machine Learning Algorithm for Detecting White Dwarfs

The Astrophysical Journal Supplement Series
White dwarfs (WDs) are the ultimate stage for approximately 97% of stars in the Milky Way and are crucial for studying stellar evolution and galaxy structure. Due to their small size and low luminosity, WDs are not easily observable.
Jiangchuan Zhang, Yude Bu, Mengmeng Zhang, Duo Xie, Zhenping Yi   +4 more
doaj   +1 more source

Leveraging Deep Learning for Time-Series Extrinsic Regression in Predicting the Photometric Metallicity of Fundamental-Mode RR Lyrae Stars

Sensors
Astronomy is entering an unprecedented era of big-data science, driven by missions like the ESA’s Gaia telescope, which aims to map the Milky Way in three dimensions.
Lorenzo Monti, Tatiana Muraveva, Gisella Clementini, Alessia Garofalo   +3 more
doaj   +1 more source

Atomically Modulating Competing Exchange Interactions in Centrosymmetric Skyrmion Hosts GdRu2X2 (X = Si and Ge)

Advanced Electronic Materials, EarlyView.
Our work bridges the gap between skyrmion discovery and material design by demonstrating how atomic‐scale control of exchange interactions enables tunable skyrmion phase transitions in centrosymmetric magnetic metals. ABSTRACT Magnetic skyrmions are topologically protected spin states that hold promise for shaping the future of electronics.
Dasuni N. Rathnaweera, Xudong Huai, K. Ramesh Kumar, Michał J. Winiarski, Tomasz Klimczuk, Allana G. Iwanicki, Satya K. Kushwaha, Martin Mourigal, Tyrel M. McQueen, Thao T. Tran   +9 more
wiley   +1 more source

Sorcha: A Solar System Survey Simulator for the Legacy Survey of Space and Time

The Astronomical Journal
The upcoming Legacy Survey of Space and Time (LSST) at the Vera C. Rubin Observatory is expected to revolutionize solar system astronomy. Unprecedented in scale, this 10 yr wide-field survey will collect billions of observations and discover a predicted ∼
Stephanie R. Merritt, Grigori Fedorets, Megan E. Schwamb, Samuel Cornwall, Pedro H. Bernardinelli, Mario Jurić, Matthew J. Holman, Jacob A. Kurlander, Siegfried Eggl, Drew Oldag, Maxine West, Jeremy Kubica, Joseph Murtagh, R. Lynne Jones, Peter Yoachim, Ryan R. Lyttle, Michael S. P. Kelley, Joachim Moeyens, Kathleen Kiker, Shantanu P. Naidu, Colin Snodgrass, Shannon M. Matthews, Colin Orion Chandler   +22 more
doaj   +1 more source

Fast Infrared Detector for Time-Domain Astronomy

Instruments
Multi-messenger astronomy and time-domain astronomy are strongly linked even if they do not have the same objectives. Multi-messenger astronomy is an astrophysical observation approach born by the simultaneous, even if casual, detection of a few events ...
Alessandro Drago
doaj   +1 more source