Results 91 to 100 of about 241,711 (290)

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Asymptotic properties of the von Foerster-Lasota equation and indices of Orlicz spaces

Electronic Journal of Differential Equations, 2016
This article concerns the asymptotic behaviour of the dynamical systems induced by the von Foerster-Lasota equation. We study chaoticity of the system in the sense of Devaney and its strong stability in Orlicz spaces generated by any phi-function.
Antoni Leon Dawidowicz, Anna Poskrobko
doaj  

Asymptotic Behaviour Functional Differential systems [PDF]

Delta Journal of Science, 2011
A functional differential system is considered. The existence and stability of the solution are investigated.
openaire   +1 more source

Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain

Advanced Science, EarlyView.
A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio, Tommaso Gili, Andrea Gabrielli, Maurizio Mattia   +3 more
wiley   +1 more source

Asymptotic Behaviour of Time Stepping Methods for Phase Field Models. [PDF]

J Sci Comput, 2021
Cheng X, Li D, Promislow K, Wetton B.
europepmc   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Stochastic Delay Lotka-Volterra Model

Journal of Inequalities and Applications, 2011
This paper examines the asymptotic behaviour of the stochastic extension of a fundamentally important population process, namely the delay Lotka-Volterra model.
Shigeng Hu, Baosheng Lian, Yang Fen
doaj  

Asymptotic behaviour of solutions to certain nonlinear third order neutral functional differential equation. [PDF]

Heliyon, 2021
Ademola AT.
europepmc   +1 more source

On the Asymptotic Behaviour of Queues

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1963
SUMMARY The homogeneous process N(t) on the lattice of integers in continuous time is discussed. When the increment probability generating function ϵ(u) is analytic at u = 1, the transition functions γn(t) = p{N(t) = n |  N(0) = 0} are Bessel-like functions with simple asymptotic properties. The asymptotic behaviour of a variety of M/G/1,
openaire   +2 more sources

Optimal Grazing Exclusion Duration to Enhance Soil Carbon Sequestration in Degraded Grasslands

Advanced Science, EarlyView.
Across China, grazing exclusion reaches the national mean soil organic carbon recovery benchmark sooner in high‐MAP regions (> 500 mm), but recovery is much slower where MAP < 300 mm. Scaling this strategy to 70% of China's degraded grasslands would sequester about 1.52 Pg of soil carbon over 10 years—roughly 17% of annual global fossil‐fuel emissions.
Bin Zhang, Chongzhi Sun, Dongmei Xue, Paul Christiaan Struik, Tongrui Zhang, Jiayue Liu, Tingting Xing, Ziyang Liu, Shiming Tang, Ke Jin   +9 more
wiley   +1 more source