Results 61 to 70 of about 1,456,492 (292)

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia   +8 more
wiley   +1 more source

"Applications of the Asymptotic Expansion Approach based on Malliavin-Watanabe Calculus in Financial Problems" [PDF]

open access: yes
This paper reviews the asymptotic expansion approach based on Malliavin-Watanabe Calculus in Mathematical Finance. We give the basic formulation of the asymptotic expansion approach and discuss its power and usefulness to solve important problems arised ...
Naoto Kunitomo, Akihiko Takahashi
core  

Beyond‐Classical Ferroelectric Metamaterials: 3D‐Printed Planar Lattices With Programmable Electro–Thermo–Mechanical Coupling

open access: yesAdvanced Science, EarlyView.
Planar ferroelectric lattices with rationally‐tailored topology and polarization achieve programmable piezoelectric and pyroelectric properties. Analytical modeling, homogenization, and experiments collectively demonstrate enhanced and tunable longitudinal, transverse, and shear piezoelectric responses, together with substantially improved ...
Jiahao Shi   +6 more
wiley   +1 more source

Asymptotic Expansion Approaches in Finance: Applications to Currency Options [PDF]

open access: yes
This chapter presents a basic of the methodology so-called an asymptotic expansion approach, and applies this method to approximation of prices of currency options with a libor market model of interest rates and stochastic volatility models of spot ...
Kohta Takehara, Akihiko Takahashi
core   +2 more sources

Quantifying the Dynamics of Network Detachment Across Scientific, Technological, Commercial, and Pharmacological Domains

open access: yesAdvanced Science, EarlyView.
Across scientific, technological, commercial, and pharmacological domains, individuals and organizations disengage from a previously adopted practice not at random, but as their network neighbors detach. The probability of detachment rises with the number of neighbors who have already disengaged. Preferential detachment reshapes network disintegration,
Binglu Wang   +5 more
wiley   +1 more source

Asymptotic approximation with Stancu Beta operators

open access: yesJournal of Numerical Analysis and Approximation Theory, 1998
The concern of this paper is a beta type operator \(L_n\) recently introduced by D.D. Stancu. We present the complete asymptotic expansion for \(L_n\) as \(n\) tends to infinity. All coefficients of \(n^{-k} \ (k=1,2, \ldots)\) are calculated explicitly
Ulrich Abel
doaj   +2 more sources

Singularly Perturbed Elliptic Dirichlet Problem with a Multiple Root of the Degenerate Equation

open access: yesМоделирование и анализ информационных систем, 2016
A singularly perturbed elliptic problem with Dirichlet boundary conditions is considered in the case of multiple roots of the degenerate equation. A complete asymptotic expansion of the solution is constructed and justified. It is qualitatively different
V. F. Butuzov, V. A. Beloshapko
doaj   +1 more source

LLM‐Assisted Design of Ultralow‐κ$\kappa$ Chalcogenides

open access: yesAdvanced Science, EarlyView.
An AI assisted, physics guided workflow accelerates the discovery of ultralow thermal conductivity materials by combining Bayesian optimization, evidence conditioned LLM reasoning, and automated physics‐based validation. The framework uncovers dynamically stable Ag based chalcogenides with ultralow thermal conductivity and promising thermoelectric ...
Yujie Liu   +9 more
wiley   +1 more source

High-order topological asymptotic expansion for Stokes equations

open access: yesElectronic Journal of Differential Equations, 2016
We use the topological sensitivity analysis method to solve various optimization problems. It consists of studying the asymptotic expansion of the objective function relative to a perturbation of the domain topology.
Mohamed Abdelwahed   +2 more
doaj  

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

open access: yesAdvanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin   +6 more
wiley   +1 more source

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