Results 21 to 30 of about 13,308,244 (177)

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

open access: yesAdvanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang   +9 more
wiley   +1 more source

Ensino-investigativo de ciências naturais e suas tecnologias nas séries iniciais do ensino fundamental [PDF]

open access: yes, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Educação e Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Educação Científica e Tecnológica.Assumindo que a escolaridade em ciência naturais, nas séries ...
Abegg, Ilse
core  

Orbital and Electrical Dual Function of Polymer Intercalant for Promoting NH4+ Storage in Vanadium Oxide Anode

open access: yesAdvanced Energy Materials, Volume 15, Issue 11, March 18, 2025.
The impact of polyaniline insertion on the atomic orbitals and electronic structure of vanadium oxide anode is systematically investigated for the first time. The electrode exhibits an outstanding capacity and unprecedent long‐term cycling life, owing to the electron transition to the V 3dxy state and the enhanced diffusion kinetics.
Yue Zhang   +6 more
wiley   +1 more source

Cell Segmentation Beyond 2D—A Review of the State‐of‐the‐Art

open access: yesAdvanced Intelligent Discovery, EarlyView.
Cell segmentation underpins many biological image analysis tasks, yet most deep learning methods remain limited to 2D despite the inherently 3D nature of cellular processes. This review surveys segmentation approaches beyond 2D, comparing 2.5D and fully 3D methods, analyzing 31 models and 32 volumetric datasets, and introducing a unified reference ...
Fabian Schmeisser   +6 more
wiley   +1 more source

Abordagem de temas em ciências da natureza no ensino médio: implicações na prática e na formação docente [PDF]

open access: yes, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Educação Científica e Tecnológica, Florianópolis, 2014.A presente pesquisa investiga práticas docentes implementadas a partir da abordagem de temas que buscam ...
Halmenschlager, Karine Raquiel
core  

Majority‐Voting Overlapping Method for Error Correction in DNA Data Storage

open access: yesAdvanced Intelligent Discovery, EarlyView.
We propose an overlapping‐based majority‐voting method for DNA data storage error correction. By aligning multiple reads and choosing the most frequent base per position, it suppresses substitution errors without prior models. Validated on synthetic and real sequencing data, it achieves high‐fidelity, scalable, and cost‐effective reconstruction ...
Thi Bich Ngoc Nguyen   +5 more
wiley   +1 more source

Seeds of change: The impact of Ethiopia's direct seed marketing approach on smallholders' seed purchases and productivity

open access: yesAmerican Journal of Agricultural Economics, EarlyView.
Abstract While multiple factors explain low adoption rates of improved varieties by small‐scale farmers in sub‐Saharan Africa, a key supply‐side constraint is the limited availability of seed embodying new traits in the volume, quality, price, and timeliness required by farmers. This constraint is partly attributable to classical failures in the market
Dawit Mekonnen   +5 more
wiley   +1 more source

Developing a strain‐dependent susceptibility to hepatocellular carcinoma in a murine model based on histopathological evidence and genetic context

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Using F1 (C57BL/6J/Smad4+/− X CC) mice, we found that partial loss of Smad4 promotes liver carcinogenesis in a strain‐dependent manner, highlighting the importance of genetic modifiers in tumor susceptibility. The use of Collaborative Cross mice provides a valuable platform for uncovering genotype‐specific cancer susceptibilities in preclinical ...
Osayd Zohud   +3 more
wiley   +1 more source

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

open access: yesArthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo   +7 more
wiley   +1 more source

O Estágio na formação acadêmico-profissional do professor de ciências: analisando o funcionamento de grupos de trabalho (GT) [PDF]

open access: yes, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Educação Científica e Tecnológica, Florianópolis, 2010Pensar o Estágio Curricular Supervisionado (ECS) realizado nas escolas como um espaço de construção de novos ...
Pires, Giselle de Souza Paula
core  

Home - About - Disclaimer - Privacy