Results 91 to 100 of about 30,325 (199)

Mesenchymal Stem Cell‐Based Therapy for Cerebellar Ataxia: From Bench to Bedside

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Allogeneic hMSCs transplanted across LPS, Ara‐C, and SCA2 cerebellar ataxia (CA) models suppress neuroinflammation and restore the neurotrophin axis, collectively preserving Purkinje cell integrity. These preclinical findings are being translated clinically, from a first‐in‐human case report to an ongoing Phase II/III randomized trial (NCT02540655 ...
Kyoungho Suk, Ho‐Won Lee, Sang Ryong Kim   +2 more
wiley   +1 more source

"ATM Gene Mutations Detection in Iranian Ataxia-Telangiectasia Patients "

Iranian Journal of Allergy, Asthma and Immunology, 2004
Ataxia-Telangiectasia (AT) is an autosomal recessive disorder involving cerebellar degeneration, immunodeficiency, radiation sensitivity and cancer predisposition.
Toshio MiyawakiMohammad Hossein Sanati, Behnaz Bayat, Ahmad Aleyasin, Hasti Atashi Shirazi, Anna Isaian, Abolhassan Farhoudi, Mostafa Moin   +6 more
doaj  

ATAXIA-TELANGIECTASIA

Medicine, 1972
D E, McFarlin, W, Strober, T A, Waldmann
openaire   +2 more sources

Combined inhibition of de novo pyrimidine synthesis and ATR promotes ATF4‐mediated cell death in TP53‐deficient ALL

HemaSphere, Volume 10, Issue 7, July 2026.
Abstract Mutations or deletions affecting the TP53 gene predict a dismal outcome in relapsed acute lymphoblastic leukemia (ALL). Loss of p53 function compromises the response to many anti‐leukemic therapies, underscoring the need for agents that are effective in TP53‐deficient cells.
Kari J. T. Grünewald, Marjolein M. G. Kes, Gawin R. Stoll, Willem P. J. Cox, Dorette S. van Ingen Schenau, Enzo M. Scutigliani, Emmely M. Wagener, Ziqin Tang, Senna Visser, Jolanda Kooiman, Jessica Buijs‐Gladdines, Maria Rodionova, Esther A. Zaal, Jeroen W. A. Jansen, Jeroen F. van Velzen, Jarno Drost, Laurens T. van der Meer, Celia R. Berkers, Frank N. van Leeuwen   +18 more
wiley   +1 more source

Regulation of Endoplasmic Reticulum Stress Suppresses Early Pro‐Tumorigenic Events During N‐Nitrosodiethylamine‐Induced Hepatocarcinogenesis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
Schematic illustration of the effect of BIX in attenuating the initiation stage of hepatocarcinogenesis. BIX pre‐treatment mitigated N‐nitrosodiethylamine‐induced ER stress, DNA damage, and downstream pro‐tumorigenic events during the initiation phase. It preserved DNA repair capacity, reduced inflammation and cellular proliferation, thereby inhibiting
Maya P. Shetty, Smita Hegde, Sanjay Bharati   +2 more
wiley   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Case Report: Neuro-Imaging Findings in Ataxia Telangiectasia

Journal of Rehabilitation, 2004
Ataxia Telangiectasia (AT) is an autosomal recessive inherited disorder in which cutaneous and scleral Telangiectasia, cerebellar ataxia and immunodeficiency occur.
Farhad Mahvelati, Seyyed Hossein Tonekaboni   +1 more
doaj  

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications

WIREs RNA, Volume 17, Issue 4, July/August 2026.
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus, Shalon Suzanne Pinto, Sai Samanvitha Madagundapalli Ramakrishna, Dechamma Pandyanada Nanjappa, Gunimala Chakraborty, Anirban Chakraborty   +5 more
wiley   +1 more source