Results 151 to 160 of about 308,172 (351)

Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia [PDF]

, 2015
Megan S. Keiser, Holly Kordasiewicz, Jodi L. McBride   +2 more
openalex   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

A Truncated Retrotransposon Disrupts the GRM1 Coding Sequence in Coton de Tulear Dogs with Bandera's Neonatal Ataxia [PDF]

, 2011
Rong Zeng, Fabiana Farias, G. S. Johnson, Stephanie McKay, Robert D. Schnabel, Jared E. Decker, Jeremy F. Taylor, C.S. Mann, Martin L. Katz, Gayle C. Johnson, Joan R. Coates, Dennis P. O’Brien   +11 more
openalex   +1 more source

Induced Proprioceptor and Low‐Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

Advanced Science, EarlyView.
This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme, Rocio K. Finol‐Urdaneta, Jeffrey R. McArthur, Nicholas R. Marzano, Simon Maksour, Amarinder Thind, Yang Guo, Dominic Kaul, Marnie Maddock, Oliver Friedrich, Boris Martinac, David J. Adams, Mirella Dottori   +12 more
wiley   +1 more source

Ataxia telangiectasia [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1964
H L, UTIAN, M, PLIT
openaire   +2 more sources

Immunoaffinity‐Mimetic Assembly of Peptide‐Aptamer Conjugates and Stem Cell‐Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair

Advanced Science, EarlyView.
Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu   +8 more
wiley   +1 more source

A Small Trinucleotide Expansion in the TBP Gene Gives Rise to a Sporadic Case of SCA17 with Abnormal Putaminal Findings on MRI [PDF]

, 2008
Ikeda, Yoshio, Jackson, Mandy, Kawarabayashi, Takeshi, Kimura, Tamaki, Matsubara, Etsuro, Miki, Yasuo, Monai, Natsuki, Seino, Yusuke, Shoji, Mikio, Suzuki, Chieko, Tomiyama, Masahiko, Wakasaya, Yasuhito, Watanabe, Mitsunori, Yamamoto-Watanabe, Yukiko   +13 more
core   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Effect of Imidazolium Concentration in Densely Functional Polymer Binder on Robust Electrochemical Kinetics and Cycling Performance of Lithium Iron Phosphate Cathode

Advanced Energy and Sustainability Research, EarlyView.
The improved performance of the cathodic half‐cell containing poly(oxycarbonylmethylene 1‐allyl‐3‐methylimidazolium) (PMAI) binder (PMAI/LFP) is attributed to the ion conduction properties of imidazolium‐functionalized polymer, which participates in cathode‐electrolyte interphase (CEI) formation as confirmed by X‐ray photoelectron spectroscopy and ...
Amarshi Patra, Zhaohan Liu, Pavithra Kasthurirangan, Noriyoshi Matsumi   +3 more
wiley   +1 more source

Probing the Kinetic Stabilities of Friedreich’s Ataxia Clinical Variants Using a Solid Phase GroEL Chaperonin Capture Platform [PDF]

, 2014
Ana R. Correia, Subhashchandra Naik, Mark T. Fisher, Cláudio M. Gomes   +3 more
openalex   +1 more source