Results 131 to 140 of about 12,825 (214)

Epidemiology of progressive cerebellar ataxia in South Yorkshire, UK. [PDF]

BMJ Neurol Open
Foster E, Shanmugarajah PD, Duty S, Hogg E, Hadjivassiliou M.   +4 more
europepmc   +1 more source

Relationships among nitrous oxide exposure, neurological injury and biomarkers

British Journal of Clinical Pharmacology, EarlyView.
Aims Recreational nitrous oxide (N2O) misuse is an increasing public health problem associated with functional cobalamin (B12) deficiency and severe neurological complications. Despite growing recognition of its harms, the dose–response relationship and clinical value of biomarkers remain unclear.
Laxna Bhujel, Angela L. Chiew, Bhashita Jagarlamudi, Pramod Chandru, Naren Gunja, Nancy Briggs, Betty S. Chan   +6 more
wiley   +1 more source

Hereditary and Non-hereditary Cerebellar Ataxias in Latvia: Six Years of Experience at the National Reference Centre (ERN-RND Affiliated Partner). [PDF]

Cerebellum
Lazdovska K, Baborikina A, Krutovs V, Rozevska M, Ķēniņa V.   +4 more
europepmc   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Deconstructing Ataxia with Oculomotor Apraxia: Toward a Gene-Based Classification and a Reappraisal of the Oculomotor Phenotype. [PDF]

Mov Disord Clin Pract
Novis LE, Filho FMR, Gomes AM, Procaci VR, Barsottini OGP, Pedroso JL.   +5 more
europepmc   +1 more source

Metabolic Ataxias in Adults.

, 2014
Metabolic ataxias are rare. They usually start in the childhood and often have autosomal recessive inheritance. They may also present in adulthood.
ANTENORA, ANTONELLA, SACCA', FRANCESCO, PELUSO, SILVIO, Santorelli FM, DE MICHELE, GIUSEPPE, FILLA, ALESSANDRO   +5 more
core  

Lithium‐related adverse drug reactions in children: A case–control study comparing lithium to second‐generation antipsychotics in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to improve the understanding of lithium's safety profile by analysing the frequency and distribution of reported adverse drug reactions (ADRs) compared to second‐generation antipsychotics (SGAs). Methods Individual case safety reports from VigiBase (1968–October 2023) involving individuals older than 2 years, with lithium or SGAs ...
Lisa T. Ringeling, Ravish N. Gangapersad, Lillian Lieuw, Patrick C. Souverein, Eibert R. Heerdink, Pilar Garcia‐Gomez, Manon H. J. Hillegers, Birgit C. P. Koch, Bram Dierckx   +8 more
wiley   +1 more source

The Real Life of Ataxia Patients Without a Vertical Family History: a Twenty-year Experience in South Brazil. [PDF]

Cerebellum
Aschoff CAM, Silva TO, Hasan A, Migliorini E, Donis KC, Rare Genomes Project Consortium, Pellerin D, Saraiva-Pereira ML, Leistner S, Poswar F, Giugliani R, Netto CBO, Ashton-Prolla P, Saute JAM, Jardim LB.   +14 more
europepmc   +1 more source

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

BMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song, Binghan Liu, Junjie Liu, Ce Li, Wenqing Man, Xurui Sun, Chang Yuan, Yanjun Wang, Hong Pan, Shuanglian Wang, Zhiming Zheng   +10 more
wiley   +1 more source

Spectrum of Hereditary Ataxia in Omani Children. [PDF]

J Clin Med
Al-Habsi A, Al-Thihli K, Al-Ajmi E, Al-Futaisi A, Al-Badi A, Al-Amrani F.   +5 more
europepmc   +1 more source