Results 161 to 170 of about 9,050 (259)

Cerebellar Ataxia [PDF]

Proceedings of the Royal Society of Medicine, 1911
openaire   +2 more sources

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

The organizational dimension in rare and complex diseases care management: an application of RarERN Path^© methodology in ataxias, dystonia and phenylketonuria. [PDF]

BMC Health Serv Res
Cannizzo S, Quoidbach V, Trieste L, Benson M, Federico A, Filla A, Gilroy BS, Giunti P, Graeßner H, Greenfield J, Hagedorn T, Hermida A, Hunt B, MacDonald A, Morgante F, Oertel W, Pastores G, Pauly MG, Reinhard C, Relja M, Treacy E, Van Spronsen F, Vallortigara J, Turchetti G.   +23 more
europepmc   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Spastic Ataxia Composite (SPAXCOM): A Scale to Evaluate the Progression of Subjects with Spasticity and Ataxia. [PDF]

Mov Disord
Di Folco C, Dubec-Fleury C, Traschütz A, Kessler C, Reich S, Gagnon C, Lessard I, Rodrigue X, Cocozza S, Satolli S, Santorelli FM, Durr A, Heinzmann A, van de Warrenburg BP, Willemse IHJ, Başak AN, Vural A, Brais B, Klebe S, Horvath R, PROSPAX Consortium, Schüle R, Synofzik M, Tezenas du Montcel S.   +23 more
europepmc   +1 more source

Interrater reliability in pediatric high‐resolution anorectal manometry recordings

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives High‐resolution anorectal manometry (HR‐ARM) is a diagnostic test assessing anorectal neuromuscular function in children with constipation and/or fecal incontinence. Interrater reliability of HR‐ARM in children has not been previously studied. The aim of this study was to assess the interrater reliability of pediatric HR‐ARM studies.
Julia M. J. van der Zande, Marc A. Benninga, Bruno P. Chumpitazi, Anil Darbari, Jose M. Garza, Julie Khlevner, Samuel Nurko, Miguel Saps, Karla Vaz, Sujithra Velayuthan, Md Rejuan Haque, Carlo Di Lorenzo, Peter L. Lu   +12 more
wiley   +1 more source

Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases. [PDF]

CPT Pharmacometrics Syst Pharmacol
Hamdan A, Traschütz A, Beichert L, Chen X, Gagnon C, van de Warrenburg BP, Santorelli FM, Başak N, Coarelli G, Horvath R, Klebe S, PROSPAX consortium, EVIDENCE‐RND consortium, Schüle R, Hooker AC, Synofzik M, Karlsson MO.   +16 more
europepmc   +1 more source

RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai, Hao Qin, Yoon Bin Chong, I‐Hsiang Chen, Shih‐Hsun Kuo, Tzu‐Ting Tseng, Ann‐Shung Lieu   +6 more
wiley   +1 more source

Two-year decline in performance on the Cerebellar Cognitive Affective Syndrome Scale in spinocerebellar ataxias. [PDF]

J Neurol
Selvadurai LP, Lo Giudice C, Wallis S, Morgan J, Kumar KR, Szmulewicz DJ, Harding IH.   +6 more
europepmc   +1 more source

Strain‐Induced Density Fluctuations in Glassy Polymers

Macromolecular Rapid Communications, EarlyView.
Strain deformation induces the density fluctuations in glassy polymers, resulting in shear‐thinning behavior. ABSTRACT Deformation of glassy polymers induces plastic flow as a result of mechanical instability, ultimately leading to cavitation and fracture of the liquid. Thus, understanding the origin of such mechanical instability is crucial.
Mikihito Takenaka, Shin'ya Yoshioka, Hirofumi Shimizu, Shotaro Nishitsuji, Sumiaki Fujii, Ryuta Izumi, Shuhei Fujita, Tadashi Inoue, Akira Furukawa   +8 more
wiley   +1 more source