Results 31 to 40 of about 13,480 (140)

Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 18, Page 5458-5475, September 2026.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle   +12 more
wiley   +1 more source

Reorientación comunitaria de la atención primaria en un área de salud: proyecto ROCAP

open access: yesAtención Primaria
Resumen: Objetivo: Evaluar la efectividad de una intervención para incorporar actividades grupales y comunitarias de forma sostenida en todas las Zonas Básicas de Salud (ZBS) de un área de salud.
Marivi Verdeguer Gómez   +5 more
doaj   +1 more source

Lesiones atendidas en atención primaria en la Comunidad de Madrid: análisis de los registros en la historia clínica electrónica

open access: yesGaceta Sanitaria, 2014
Objetivo: Describir la incidencia de lesiones atendidas en atención primaria y analizar su distribución según el tipo de lesión por sexo y edad en la Comunidad de Madrid en el año 2011.
Ana Clara Zoni   +3 more
doaj   +1 more source

Supervised Exercise Intervention Restores Physical Activity and MultiOMIC‐Derived Frailty Biomarkers in Older Adults

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The molecular mechanisms underlying frailty are under intense investigation. Independent observational studies revealed various biological processes and biomarkers differentially expressed in frail individuals and after interventions.
Diego Marcos‐Perez   +10 more
wiley   +1 more source

Análisis de la salud de la población sin hogar de un distrito desfavorecido de Barcelona. Estudio ESSELLA

open access: yesAtención Primaria, 2022
Resumen: Objetivo: Conocer el estado de salud de la población sin hogar. Diseño: Estudio descriptivo transversal. Emplazamiento: Centro de Salud de Atención Primaria de Raval Sud (Barcelona).
Daniel Roca Lahiguera   +5 more
doaj   +1 more source

Adaptation of the International Consortium for Health Outcomes Measurement Standard Set for Inflammatory Bowel Disease for Routine Collection in Clinical Practice

open access: yesJCC Plus, Volume 1, Issue 4, July 2026.
ABSTRACT Background and Aims Value‐based healthcare (VBHC) is based on evaluating clinical interventions according to their ability to improve outcomes and costs to finally enhance quality of care. As part of an initiative to introduce VBHC in inflammatory bowel disease (IBD), our project aimed to adapt the International Consortium for Health Outcomes ...
Xavier Calvet   +33 more
wiley   +1 more source

Hepatitis B virus infection and vaccine-induced immunity in Madrid (Spain)

open access: yesGaceta Sanitaria, 2014
Objective: To estimate the prevalence of hepatitis B virus (HBV) infection and vaccine-induced immunity in the region of Madrid, and to analyze their evolution over time. Methods: An observational, analytical, cross-sectional study was carried out in the
Ana María Pedraza-Flechas   +6 more
doaj   +1 more source

Home‐Based Versus In‐Hospital Care in Pediatrics: A Systematic Review of Cost‐Effectiveness Studies

open access: yesWorld Medical &Health Policy, Volume 18, Issue 2, June 2026.
ABSTRACT Home‐based care has emerged as a potential alternative to traditional hospital‐based care for children and adolescents worldwide. This systematic review aimed to systematically gather and critically assess the available evidence on the cost‐effectiveness of home‐based versus in‐hospital care for pediatric populations globally.
Luís Carlos Lopes‐Júnior   +8 more
wiley   +1 more source

Prevalencia del miedo a caer y factores asociados en personas mayores que viven en la comunidad

open access: yesAtención Primaria, 2021
Resumen: Objetivo: El objetivo general del estudio es conocer la prevalencia de la preocupación a caer en personas mayores, independientes para la deambulación, que viven en la comunidad, según la versión reducida del FES-I y los factores asociados que ...
Nuria Alcolea-Ruiz   +5 more
doaj   +1 more source

Endocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study

open access: yesAddiction, Volume 121, Issue 5, Page 1179-1189, May 2026.
Abstract Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.
María Salud García‐Gutiérrez   +5 more
wiley   +1 more source

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