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Noninvasive Coronary Atherosclerotic Plaque Imaging
JACC: Cardiovascular Imaging, 2023Coronary artery disease is the leading cause of morbidity and mortality worldwide. Despite remarkable advances in the management of coronary artery disease, the prediction of adverse coronary events remains challenging. Over the preceding decades, considerable effort has been made to improve risk stratification using noninvasive imaging.
Jacek Kwiecinski +7 more
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Development of atherosclerotic plaques
Acta Medica Scandinavica, 1985ABSTRACT. Atherosclerosis is a multifactorial disease. A unified model for the lesion development reveals many connections between the response‐to‐injury hypothesis and the lipid hypothesis. Various cellular uptake mechanisms for native and modified lipoproteins are discussed with respect to foam cell formation and lesion development.
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MR imaging of atherosclerotic plaque
Radiologic Clinics of North America, 2002MRI is a powerful noninvasive imaging tool with high spatial resolution that continues to prove its value in determining atherosclerotic plaque size, volume, and tissue components. Multispectral MRI sequences have been validated to characterize atherosclerotic plaque components in animals; they have recently been applied to human aorta and carotid ...
C Joon, Choi, Christopher M, Kramer
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Atherosclerotic plaque imaging
2022Abstract Aside from coronary artery stenosis assessment, coronary CT angiography (CCTA) provides a large amount of data on plaque extent, distribution, morphology, and composition, which may facilitate a more refined risk stratification of the patient. Calcified plaque components can be easily distinguished from non-calcified parts based
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Investigation of Atherosclerotic Plaque Vulnerability
2022Histochemical and immunohistochemical approaches permit the detection and evaluation of proteins and cell types within murine brachiocephalic artery atherosclerotic plaques, that can be subsequently analyzed to provide inferences on atherosclerotic plaque vulnerability.
George, Sarah J, Johnson, Jason L
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Apoptosis in human atherosclerotic plaques
Apoptosis, 1999Intimal cell death has been a recognized feature of advanced atherosclerotic disease. With the advent of DNA in situ end labelling and/or ultrastructural techniques, recent findings suggest that cells of an atheroma undergo programmed cell death or apoptosis. The pathophysiologic relevance of apoptosis in atherosclerotic disease is debatable. Apoptotic
F D, Kolodgie +3 more
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2009
Even though coronary, cerebral, and peripheral arterial disease represents the most common features of atherosclerosis, it progresses in the absence of any symptoms for most of its developmental course. Generally, the severity of a coronary stenosis is of poor predictive value for cardiac events such as sudden death, myocardial infarction, or unstable ...
Maddalena Piro +2 more
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Even though coronary, cerebral, and peripheral arterial disease represents the most common features of atherosclerosis, it progresses in the absence of any symptoms for most of its developmental course. Generally, the severity of a coronary stenosis is of poor predictive value for cardiac events such as sudden death, myocardial infarction, or unstable ...
Maddalena Piro +2 more
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Agents that stabilise atherosclerotic plaque
Expert Opinion on Investigational Drugs, 2003The concept of plaque stabilisation was developed to explain how medications could decrease adverse coronary events without a substantial reduction in the regression of atherosclerosis. With this concept, a comprehensive view of atherosclerosis is now appreciated.
Jun R, Chiong, Alan B, Miller
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Atherosclerotic Plaque Imaging
2017Cardiovascular diseases (CVD) remain the leading cause of death in western societies and developing countries despite improvements in prevention, diagnosis and treatment. Coronary artery disease (CAD) and myocardial infarction (MI) account for more than 50% of CVD deaths and are the result of coronary atherosclerosis and plaque rupture and subsequent ...
Plaza, Begona Lavin +3 more
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Evaluation of Coronary Atherosclerotic Plaques
Cardiology Clinics, 2009In many patients, unheralded myocardial infarction associated with a mortality of approximately 20% is the first manifestation of coronary artery disease. Approximately 40% of the population is considered to have a moderate midterm risk of 10% to 20%. Any of the stratification schemes suffers from a lack of accuracy to correctly determine the risk, and
Christoph R, Becker, Tobias, Saam
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