Results 231 to 240 of about 892,504 (360)

Genomic atlas of the human plasma proteome

Nature, 2018
B. Sun, J. Maranville, J. Peters, D. Stacey, James R. Staley, James A. Blackshaw, S. Burgess, T. Jiang, Ellie Paige, P. Surendran, C. Oliver‐Williams, M. Kamat, B. Prins, Sheri K. Wilcox, E. Zimmerman, An Chi, N. Bansal, S. Spain, A. Wood, N. Morrell, J. Bradley, N. Janjić, David J. Roberts, W. Ouwehand, J. Todd, N. Soranzo, K. Suhre, D. Paul, C. Fox, R. Plenge, J. Danesh, H. Runz, A. Butterworth   +32 more
semanticscholar   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

A unified single-cell atlas of HNSCC: Toward characterizing HPV- and sex-associated TME variability. [PDF]

iScience
Conde-Lopez C, Marripati D, Besso MJ, Roscher M, Han R, Hadiwikarta WW, Elkabets M, Hess J, Kurth I.   +8 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Brain parcellation for TMD neuroimaging: a critical narrative review. [PDF]

BDJ Open
Savychuk N, Pekhno V, Liakhovska A, Sulik R, Riabko I.   +4 more
europepmc   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Optimized Wire Grid Modeling Method for Complex Metal Mesh Fabrics Using Waveguide-Contact Measurement. [PDF]

Sensors (Basel)
Park K, Lee S, Park IS, Seo CW, Yoon SS, Lee JW.   +5 more
europepmc   +1 more source

IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030.

Diabetes Research and Clinical Practice, 2011
D. Whiting, L. Guariguata, C. Weil, J. Shaw   +3 more
semanticscholar   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Atlas Covidicus

The American Journal of Medicine, 2021
openaire   +3 more sources