Results 231 to 240 of about 596,401 (334)

Volumetric atlas of the rat inner ear from microCT and iDISCO+ cleared temporal bones. [PDF]

PeerJ
Cossellu D, Vivado E, Batti L, Gantar I, Pizzala R, Perin P.   +5 more
europepmc   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

MegaTrack: a framework for the anatomically accurate and time-efficient virtual dissection and analysis of large-scale tractography datasets

Dell'Acqua F, Beyh A, Stones R, Barrett RL, De Santiago Requejo F, Laguna PL, Lacerda LM, Davison C, Leslie A, Howells H, Goldstein LH, Williams SC, Catani M.   +12 more
europepmc   +1 more source

Post-Traumatic Longitudinal Atlanto-Occipital Dissociation without Neurodeficits Treated with Visor (Head-Neck-Chest ) Orthosis - a Rare Case Report and Review of the Literature. [PDF]

J Orthop Case Rep
Sakhrekar R, Keane C, Woo E, Knapman M, McCann MR, Gray R.   +5 more
europepmc   +1 more source

An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer

Advanced Science, EarlyView.
This study presents an explainable multimodal AI model, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing), that combines whole‐slide histopathology with clinical data for accurate germline BRCA1/2 mutation prescreening. By integrating digital pathology and EHR phenotypes, MAIGCT enables cost‐effective, scalable hereditary breast ...
Zijian Yang, Changyuan Guo, Jiayi Li, Yalun Li, Lei Zhong, Pengming Pu, Tongxuan Shang, Lin Cong, Yongxin Zhou, Guangdong Qiao, Ziqi Jia, Hengyi Xu, Heng Cao, Yansong Huang, Tianyi Liu, Jian Liang, Jiang Wu, Dongxu Ma, Yuchen Liu, Ruijie Zhou, Xiang Wang, Jianming Ying, Meng Zhou, Jiaqi Liu   +23 more
wiley   +1 more source

Functional tissue units in the Human Reference Atlas. [PDF]

Nat Commun
Bidanta S, Börner K, Herr Ii BW, Quardokus EM, Nagy M, Gustilo KS, Bajema R, Maier E, Molontay R, Weber GM.   +9 more
europepmc   +1 more source

Discovery to Engineering of Mycotoxin Deoxynivalenol Degrading Enzymes Based on the Specialized Glyoxalase I

Advanced Science, EarlyView.
Deoxynivalenol (DON), a prevalent food mycotoxin, is an important risk factor in global food safety. A molecular phylogeny‐guided engineering approach is devised to repurpose specialized glyoxalase I (SPG) as a DON deactivator. Engineered SPG variants demonstrate superior stability and are highly capable of converting DON into less toxic products ...
Seung Hee Lee, Song Lim Ham, Kyoungmi Oh, Hyojin Park, Young‐Seo Kang, Tae‐Joo Yang, Taekyung Kim, Jonghwan Kim, Gyu Sung Lee, Min‐Jeong Lee, Jin‐Byung Park, Chung Sub Kim, Nam Yoon Kim   +12 more
wiley   +1 more source

A web-based histology atlas for the freshwater sentinel species Daphnia magna. [PDF]

Sci Total Environ
Ngu MS, Vanselow DJ, Zaino CR, Lin AY, Copper JE, Beaton MJ, Orsini L, Colbourne JK, Cheng KC, Ang KC.   +9 more
europepmc   +1 more source

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He, Zi‐Yi Wang, Bin Xu, Cheng‐Jie Zhong, Lu‐Na Wang, Huan‐Chen Shi, Zi‐Yue Yang, Shi‐Qi Zhou, Hui Li, Bo Hu, Xiao‐Dong Zhu, Ying‐Hao Shen, Jian Zhou, Jia Fan, Hui‐Chuan Sun, Cheng Huang   +15 more
wiley   +1 more source

Spatial neglect after subcortical stroke may reflect cortico-cortical disconnection. [PDF]

Sci Rep
Sperber C, Rosenzopf H, Wawrzyniak M, Klingbeil J, Saur D, Karnath HO.   +5 more
europepmc   +1 more source