Results 101 to 110 of about 957,277 (312)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Da gestão multidimensional à gestão decolonial da educação

Política e Gestão Educacional
A pesquisa reflete sobre a gestão educacional decolonial, centrada na discussão sobre interculturalidade na perspectiva do modelo de gestão educacional multidimensional. Empreendeu-se uma análise temática reflexiva do podcast ‘Essa Geração’, temporada 6
Fabiana Pinto de Almeida Bizarria, Flávia Lorenne Sampaio Barbosa, Telma Maria dos Santos Nascimento, Edileusa Maria Lobato Pereira   +3 more
doaj   +1 more source

Atlas.ti as a tool for analysis of qualitative research according phenomenological approach [PDF]

ETD: Educação Temática Digital, 2014
There’s, in the context of research in the humanities and social sciences, an emerging discussion about the use of new technologies in analytical processes, therefore, what concerns to the use of qualitative or quantitative data analysis software.
Kluber, Tiago Emanuel
doaj  

Publication patterns in HEP computing

, 2012
An overview of the evolution of computing-oriented publications in high energy physics following the start of operation of LHC. Quantitative analyses are illustrated, which document the production of scholarly papers on computing-related topics by high ...
Basaglia, T., Bell, Z. W., Dressendorfer, P. V., Pia, M. G.   +3 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Measurement of the total cross section at 8 TeV and the inelastic cross section at 13 TeV at the LHC with the ATLAS detector

, 2016
New measurements from ATLAS at the LHC are presented on the total cross section at $\sqrt{s}=8$ TeV from elastic scattering using the ALFA sub-detector and on the inelastic cross section at $\sqrt{s}=13$ TeV using the MBTS sub-detector.Comment ...
Stenzel, H.
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Análises das diretrizes para o apoio institucional das gestões da Atenção Básica das capitais brasileiras

Saúde em Debate
Objetivou-se investigar os limites e as potencialidades das diretrizes gerais das gestões da Atenção Básica das capitais brasileiras para o apoio institucional. O estudo é descritivo, exploratório, qualitativo, realizado de fevereiro a outubro de 2014, a
Lygia Maria de Figueiredo Melo, Claudia Santos Martiniano, Jacileide Guimarães, Marize Barros de Souza, Paulo de Medeiros Rocha   +4 more
doaj   +1 more source

Choosing ICT Tools: Proposition of a Model to Deliver Value for Clients

Journal of Technology Management & Innovation, 2013
Several tools of Information and Communication Technology (ICT) are being used nowadays to support customer relationship processes. Literature review shows that, in the selection and deployment of these tools, internal goals of productivity and ...
Paulo Grise, Melby Karina Zuniga Huertas
doaj   +1 more source

Recent Progress in the Symmetric Generation of Groups

, 2010
Many groups possess highly symmetric generating sets that are naturally endowed with an underlying combinatorial structure. Such generating sets can prove to be extremely useful both theoretically in providing new existence proofs for groups and ...
Fairbairn, Ben
core   +1 more source