Results 261 to 270 of about 2,793,510 (386)

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun   +10 more
wiley   +1 more source

Epithelial Cell Mechanoresponse to Matrix Viscoelasticity and Confinement Within Micropatterned Viscoelastic Hydrogels

open access: yesAdvanced Science, EarlyView.
Extracellular matrix (ECM) viscoelasticity and spatial confinement regulate cellular processes such as cancer progression, yet their interplay remains poorly understood. By developing fibronectin (FN)‐micropatterned viscoelastic hydrogels mimicking breast cancer mechanics, this study explores breast epithelial cell mechanoresponse to ECM ...
Giuseppe Ciccone   +6 more
wiley   +1 more source

Wave ripples formed in ancient, ice-free lakes in Gale crater, Mars. [PDF]

open access: yesSci Adv
Mondro CA   +15 more
europepmc   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

open access: yesAdvanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang   +16 more
wiley   +1 more source

The elusive nature of Martian liquid brines. [PDF]

open access: yesProc Natl Acad Sci U S A
Chevrier VF, Slank RA.
europepmc   +1 more source

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