Results 71 to 80 of about 112,404 (309)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

MISSION PROFILE AND DESIGN CHALLENGES FOR MARS LANDING EXPLORATION [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2017
An orbiter and a descent module will be delivered to Mars in the Chinese first Mars exploration mission. The descent module is composed of a landing platform and a rover.
J. Dong, Z. Sun, W. Rao, Y. Jia, L. Meng, C. Wang, B. Chen   +6 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Effects of the 2018 Martian Global Dust Storm on Boundary Positions in the Induced Magnetosphere

The Planetary Science Journal
Global dust storms at Mars have a significant impact on the atmosphere and ionosphere, but only recently has their impact on the magnetosphere been investigated.
Catherine E. Regan, Andrew J. Coates, Mark Lester, Anne Wellbrock, Geraint H. Jones, Beatriz Sánchez-Cano, Philippe Garnier, Louisa J. Preston, František Němec, Václav Linzmayer, Rudy A. Frahm, Mats Holmström   +11 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

A Simple Subgrid‐Scale Model for Slope Winds on Mars

Earth and Space Science
Global Climate Models (GCMs) are useful tools for simulating the dynamics of Mars atmosphere on a planetary scale. However their coarse resolution (∼100 km) does not allow to capture small‐scale phenomena such as slope winds which can occur over scales ...
T. Pierron, F. Forget, E. Millour, A. Spiga, A. Martinez   +4 more
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Quantification of Carbonates, Oxychlorines, and Chlorine Generated by Heterogeneous Electrochemistry Induced by Martian Dust Activity

Geophysical Research Letters, 2023
Heterogeneous electrochemistry induced by Martian dust activity is an important type of atmosphere‐surface interaction that affects geochemical processes at the Martian surface and in the Martian atmosphere.
Alian Wang, Andrew W. Jackson, Neil C. Sturchio, Jen Houghton, Chuck Y. C. Yan, Kevin S. Olsen, Quincy H. K. Qu   +6 more
doaj   +1 more source

Breeding vectors and predictability in the Oxford Mars GCM [PDF]

, 2003
A breeding vectors approach is used to study the intrinsic predictability of the Martian atmosphere using the Oxford Mars General Circulation Model (MGCM).
Lewis, S.R., Newman, C.E., Read, P.L.
core  

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source