Results 41 to 50 of about 1,062,869 (306)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Air pollution modelling using a graphics processing unit with CUDA [PDF]
, 2009 The Graphics Processing Unit (GPU) is a powerful tool for parallel computing. In the past years the performance and capabilities of GPUs have increased, and the Compute Unified Device Architecture (CUDA) - a parallel computing architecture - has been ...
Lagzi, Istvan +3 more
core +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
South African Journal of Science, 2009 The relatively recently developed scintillometry method, with a focus on the dual-beam surface layer scintillometer (SLS), allows boundary layer atmospheric turbulence, surface sensible heat and momentum flux to be estimated in real-time.
G. Odhiambo, M. Savage
doaj
Remote Sensing, 2020 Retrieval of land surface temperature (LST) from satellite data allows to estimate the surface urban heat island (SUHI) as the difference between the LST obtained in the urban area and the LST of its surroundings.
José Antonio Sobrino, Itziar Irakulis
doaj +1 more source
Using the Dynamic Appraisal of Situational Aggression (DASA) to assess the impact of unit atmosphere on violence risk assessment [PDF]
, 2023 Melanie Simmons +4 more
openalex +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Neutrino cross sections at high energies and the future observations of ultrahigh-energy cosmic rays
, 2002 We show that future detectors of ultrahigh-energy cosmic-ray neutrinos will be able to measure neutrino-nucleon cross section at energies as high as 10^{11}GeV or higher. We find that the flux of up-going charged leptons per unit surface area produced by
A. Vilenkin +42 more
core +1 more source
Cubic di-μ-amido-bis[bis(η5-cyclopentadienyl)ytterbium(III)] [PDF]
, 2007 The title compound, [Yb2(C5H5)4(NH2)2], was synthesized in a Parr high-pressure vessel starting from monoclinic [Cp2YbNH2]2 (where Cp = cyclopentadienyl).
Schnick, Wolfgang, Zeuner, Martin
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source