Results 101 to 110 of about 391,633 (331)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Barium abundance in red giants of NGC 6752. Non-local thermodynamic equilibrium and three-dimensional effects

, 2012
(Abridged) Aims: We study the effects related to departures from non-local thermodynamic equilibrium (NLTE) and homogeneity in the atmospheres of red giant stars in Galactic globular cluster NGC 6752, to assess their influence on the formation of Ba II ...
A. Kučinskas, Andrievsky, Asplund, Behara, Bonifacio, Caffau, Caffau, Carretta, Carretta, Carretta, Carretta, Castelli, Cohen, Collet, Collet, Decressin, D’Ercole, E. Caffau, Freytag, González Hernández, Gratton, Gratton, H.-G. Ludwig, Harris, James, Korotin, Korotin, Kraft, Kupka, Kurucz, Ludwig, Mashonkina, Mashonkina, Mashonkina, Mishenina, Norris, Norris, Otsuki, P. Bonifacio, Pasquini, Piotto, Piotto, Ramírez, Roederer, S. A. Korotin, S. M. Andrievsky, Sbordone, Sbordone, Shen, Short, Sneden, Sneden, Sneden, Sobeck, Suntzeff, T. V. Mishenina, V. Dobrovolskas, Yong   +57 more
core   +2 more sources

The Primeval Atmosphere [PDF]

Science, 1906
n ...
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Investigation of ρ Cas (HR 9045, HD 224014) stellar atmosphere [PDF]

Serbian Astronomical Journal
The atmosphere of hypergiant ρ Cas is investigated by the method of atmospheric model. Effective temperature and the surface of gravity are determined by comparing the observed and theoretical values of photometrical indices [c1];Q, and ...
Samedov Z.A., Hajieva G.M.
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Fotografías de la casa Santa Julia: Nicolás Rupcich

ARQ, 2012
Este registro fotográfico de una obra reciente en las afueras de Santiago construye un pequeño universo doméstico donde, por medio de la arquitectura, se encuentran el territorio, los ritos de la vida familiar y posesiones acumuladas en el tiempo.A set ...
Nicolás Rupcich, Emilio Marín
doaj  

Basics of the NLTE physics

, 2014
Basic assumptions of the NLTE approximation in stellar atmospheres are summarized. The assumptions of thermodynamic equilibrium, local thermodynamic equilibrium (LTE), and non-LTE (NLTE) are compared.
Kubát, Jiří
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source