Results 121 to 130 of about 391,633 (331)

Atmospheres of choreographic design [PDF]

open access: yes, 2015
The artistic and technical investigations of the Design and Performance Lab, based at Brunel University in London (UK) and co-directed by Johannes Birringer and Michèle Danjoux, have encompassed research into how costumes and specially designed body-worn
Birringer, J, Danjoux, M
core  

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

open access: yesFEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo   +11 more
wiley   +1 more source

Direct Observation of Molecular Oxygen Production from Carbon Dioxide

open access: yes, 2016
Oxygen ($O_2$) is one of the most important elements required to sustain life. The concentration of $O_2$ on Earth has been accumulated over millions of years and has a direct connection with that of $CO_2$.
Baltuška, Andrius   +7 more
core   +2 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

Der Raum ist der Freund des Seins. Bachelards Poetik des Raumes als Anstoß zu einer neuen Betrachtung des sozialen Raumes

open access: yesSub\urban, 2015
Der folgende Text versucht, eine neue Perspektive auf die in der Sozialwissenschaft anhaltende Raumdebatte um den „spatial turn“ zu entwickeln. Hauptanliegen ist es, die darin waltende unproduktive Dichotomisierung von Raumessenzialismus versus ...
Thomas Dörfler
doaj  

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

open access: yesFEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh   +2 more
wiley   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

open access: yesFEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto   +5 more
wiley   +1 more source

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