Results 121 to 130 of about 399,430 (333)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
First simulations with a whole atmosphere data assimilation and forecast system: The January 2009 major sudden stratospheric warming [PDF]
, 2011 Houjun Wang +5 more
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Atmospheres and science fiction
Cogent Arts & Humanities, 2019 This article proposes to read science fiction through the lens of atmosphere. Atmospheres, of course, have gained increased critical interest in recent years, most noticeably in Hans Ulrich Gumbrecht’s monograph Atmosphere, Mood, Stimmung, but also ...
Steen Ledet Christiansen
doaj +1 more source
Exonephology: transmission spectra from a 3D simulated cloudy atmosphere of HD 209458b [PDF]
, 2018 Stefan Lines +10 more
openalex +1 more source
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
Infrared spectra of planetary atmospheres [PDF]
The development of high spectral resolution and highly sensitive long infrared wavelength instruments is reported. This instrumentation is used to examine molecular lines in planetary atmospheres in enough detail to obtain new information about these ...
Townes, C. H.
core +1 more source
Potential Biosignatures in Super-Earth Atmospheres II. Photochemical Responses [PDF]
, 2013 John Lee Grenfell +8 more
openalex +1 more source