Results 71 to 80 of about 399,430 (333)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Geophysical Research Letters, 2008 A primary concern of CO2‐induced warming is the associated rise of tropical (10S‐10N) sea‐surface temperatures (SSTs). GISS Model‐E was used to produce two sets of simulations‐one with the present‐day and one with doubled CO2 in the atmosphere.
Y. C. Sud +5 more
doaj +1 more source
The Influence of Galactic Cosmic Rays on Ion-Neutral Hydrocarbon Chemistry in the Upper Atmospheres of Free-Floating Exoplanets [PDF]
, 1989 Cosmic rays may be linked to the formation of volatiles necessary for prebiotic chemistry. We explore the effect of cosmic rays in a hydrogen-dominated atmosphere, as a proof-of-concept that ion-neutral chemistry may be important for modelling hydrogen ...
C. Bilger +5 more
core +3 more sources
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Photochemistry in Terrestrial Exoplanet Atmospheres III: Photochemistry and Thermochemistry in Thick Atmospheres on Super Earths and Mini Neptunes [PDF]
, 2013 Some super Earths and mini Neptunes will likely have thick atmospheres that are not H2-dominated. We have developed a photochemistry-thermochemistry kinetic-transport model for exploring the compositions of thick atmospheres on super Earths and mini ...
Hu, Renyu, Seager, Sara
core +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
The Response of Tropical Rainfall to Idealized Small‐Scale Thermal and Mechanical Forcing
Geophysical Research LettersPredicting the spatiotemporal distribution of rainfall remains a key challenge in Tropical Meteorology, partly due to an incomplete understanding of the effects of different environmental factors on atmospheric convection.
Martin Velez‐Pardo, Timothy W. Cronin
doaj +1 more source
Analysis of Interstellar Extinction towards the Hypergiant Cyg OB2 No. 12
Open Astronomy, 2016 The Cyg OB2 stellar association hosts an entire zoo of unique objects, and among them – an enigmatic star Cyg OB2 No. 12 (Schulte 12, MT 304). MT 304 is enigmatic not only due to its highest luminosity (according to various estimates, it is one of the ...
Maryeva O. V. +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source