Results 191 to 200 of about 43,943 (330)

Accounting for Intra‐ and Intergenomic Sequence Variation in Reference Barcodes Improves eDNA Metabarcoding Biodiversity Assessment

open access: yesMolecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT Environmental DNA (eDNA) metabarcoding can rapidly characterise biodiversity, yet its accuracy and effectiveness are limited by incomplete DNA barcode reference databases. We evaluated how comprehensive reference databases that include sequence variation within genomes (intragenomic) and across individuals and species (intergenomic) improve ...
Luke J. McCartin   +11 more
wiley   +1 more source

pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma

open access: yesActa Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal ...
Albrecht Schwab   +37 more
wiley   +1 more source

U/Th Dating of Secondary Carbonate Deposits in Underground Galleries of Fourvière Hill (Lyon, France) Reveals a Water Supply System in Operation From the Roman Period to the Middle Ages

open access: yesArchaeometry, Volume 68, Issue 2, Page 286-295, April 2026.
ABSTRACT The recent discovery of a water draining structure known as the Antiquaille galleries in Fourvière hill, in the center of Lyon, France (ancient Lugdunum), sheds light on the water drainage system built by the former inhabitants of this area for their water needs.
E. Pons‐Branchu   +7 more
wiley   +1 more source

CBP/β‐Catenin Signaling in Hepatocytes Plays Pivotal Roles in MMP‐7‐Mediated Liver Fibrosis in a Metabolic Dysfunction‐Associated Steatohepatitis Mouse Model

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CDAHFD‐induced hepatic steatosis stimulates CBP/β‐catenin signaling in hepatocytes, leading to increased production of the downstream effector MMP‐7. Hepatocyte‐derived MMP‐7 contributes to fibrogenic responses and is associated with the progression of liver fibrosis.
Jun Imamura   +5 more
wiley   +1 more source

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