Results 51 to 60 of about 695,317 (311)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Atmosphere: An International and Interdisciplinary Scientific Open Access Journal

Atmosphere, 2010
The new online, Open Access journal Atmosphere has been launched to present reviews, regular research papers, communications and short notes on atmospheric topics. These topics include experimental and theoretical work related to the physical atmosphere,
Daniela Jacob
doaj   +1 more source

Some Measured Characteristics of Severe Storm Turbulence [PDF]

, 1962
Measurements of atmospheric turbulence obtained from airplane flights through severe storms in connection with the National Severe Storms Project will be discussed.
Rhyne, Richard H., Steiner, Roy
core   +1 more source

Hot Jupiter atmospheric flows at high resolution [PDF]

Monthly Notices of the Royal Astronomical Society, 2020
ABSTRACT Global circulation models (GCMs) of atmospheric flows are now routinely used to interpret observational data on hot Jupiters. Localized ‘equatorial β-plane’ simulations have revealed that a barotropic (horizontal shear) instability of the equatorial jet appears at horizontal resolutions beyond those typically achieved in global ...
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Improving the Quasi‐Biennial Oscillation via a Surrogate‐Accelerated Multi‐Objective Optimization

Journal of Advances in Modeling Earth Systems
Accurate simulation of the quasi‐biennial oscillation (QBO) is challenging due to uncertainties in representing convectively generated gravity waves.
Luis Damiano, Walter Hannah, Chih‐Chieh Chen, James J. Benedict, Khachik Sargsyan, Bert J. Debusschere, Michael S. Eldred   +6 more
doaj   +1 more source

The Atmospheric Gray-Zone (a.k.a. Terra Incognita) Problem: A Strategy Analysis from an Engineering Viewpoint

Fluids
The Terra Incognita (or gray-zone) problem seen in atmospheric flow simulations causes serious consequences: it implies, e.g., significantly incorrect flow predictions and results that often simply depend on flow simulation settings as the computational ...
Stefan Heinz
doaj   +1 more source

Estimating the mortality burden attributable to temperature and PM2.5 from the perspective of atmospheric flow

Environmental Research Letters, 2020
The flow of the Earth’s atmosphere not only largely determines its temperature status, but also profoundly affects aerosol concentrations. Therefore, exploring how to evaluate the synthetical effects of temperature and aerosol pollution on human health ...
Ling Han, Zhaobin Sun, Juan He, Bihui Zhang, Mengyao Lv, Xiaoling Zhang, Canjun Zheng   +6 more
doaj   +1 more source

Atmospheric Circulation of Hot Jupiters: A Shallow Three-Dimensional Model

, 2009
Remote observing of exoplanetary atmospheres is now possible, offering us access to circulation regimes unlike any of the familiar Solar System cases. Atmospheric circulation models are being developed to study these new regimes but model validations and
Barman, Barman, Barman, Burrows, Burrows, Burrows, Charbonneau, Charbonneau, Charbonneau, Cho, Cho, Cooper, Cooper, Deming, Deming, Dobbs-Dixon, Ehrenreich, Eliassen, Emily Rauscher, Fortney, Fortney, Fortney, Goodman, Grillmair, Henry, Holton, Hubeny, Knutson, Knutson, Kristen Menou, Langton, Langton, Marcy, Marley, Menou, Pedlosky, Rauscher, Rauscher, Redfield, Salby, Seager, Seager, Showman, Showman, Spiegel, Sudarsky, Torres, Vallis, Washington, Zahnle   +49 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source