Results 61 to 70 of about 695,317 (311)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Vertical Coherence of Turbulence in the Atmospheric Surface Layer: Connecting the Hypotheses of Townsend and Davenport [PDF]

open access: yes, 2019
Statistical descriptions of coherent flow motions in the atmospheric boundary layer have many applications in the wind engineering community. For instance, the dynamical characteristics of large-scale motions in wall-turbulence play an important role in ...
Baars, Woutijn J.   +3 more
core   +3 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Applicability Study of Euler–Lagrange Integration Scheme in Constructing Small-Scale Atmospheric Dynamics Models

open access: yesAtmosphere
The atmospheric flow field and weather processes exhibit complex and variable characteristics at small scales, involving interactions between terrain features and atmospheric physics.
Xiangqian Wei   +4 more
doaj   +1 more source

Dramatic spectral transition of X-ray pulsar GX 304-1 in low luminous state

open access: yes, 2018
We report on the discovery of a dramatic change in the energy spectrum of the X-ray pulsar GX 304-1 appearing at low luminosity. Particularly, we found that the cutoff power-law spectrum typical for accreting pulsars, including GX 304-1 at higher ...
Doroshenko, Victor   +7 more
core   +1 more source

Changing Face of the Extrasolar Giant Planet, HD 209458b [PDF]

open access: yes, 2002
High-resolution atmospheric flow simulations of the tidally-locked extrasolar giant planet, HD 209458b, show large-scale spatio-temporal variability. This is in contrast to the simple, permanent day/night (i.e., hot/cold) picture.
Bradley M. S. Hansen   +4 more
core   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Influence of Planetary Rotation on Supersonic Flow of Lava Planets: A Two-dimensional Horizontal Model Analysis

open access: yesThe Astrophysical Journal
The study of lava planets has attracted significant attention recently because of their close proximity to their host stars, which enhances their detectability for atmospheric characterization.
Zhuo-Yang Song, Feng Ding, Wanying Kang
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

Rarefied gas flows through meshes and implications for atmospheric measurements [PDF]

open access: yesAnnales Geophysicae, 2001
Meshes are commonly used as part of instruments for in situ atmospheric measurements. This study analyses the aerodynamic effect of meshes by means of wind tunnel experiments and numerical simulations. Based on the Direct Simulation Monte Carlo method,
J. Gumbel
doaj   +1 more source

Home - About - Disclaimer - Privacy