Results 141 to 150 of about 134,760 (296)

Nanoelectrode Atmospheric Pressure Chemical Ionization Mass Spectrometry

Journal of the American Society for Mass Spectrometry
A small ionization needle with an ultrasharp, ultrafine tip is introduced. It is lab-fabricated from tungsten wire and serves as a corona discharge emitter in nanoelectrode atmospheric pressure chemical ionization mass spectrometry (nAPCI-MS). Tip radii ranged from 8 to 44 nm, up to 44× smaller than the sharpest previously reported corona needle ...
Nicole C. Auvil, Mark E. Bier
openaire   +2 more sources

Flexible and High‐Performance Perovskite‐Polymer Composites for Dual X‐Ray and Proton Direct Detection

Advanced Optical Materials, EarlyView.
A polymer–perovskite composite obtained by mechanochemical synthesis enables thick, tunable active layers for efficient absorption of highly penetrating ionizing radiation. Vertical‐electrode detectors achieve low X‐ray detection limits and high sensitivity direct 5 MeV proton sensing.
Camilla Bordoni, Bas A. H. Huisman, Joost W. C. Reinders, Ilaria Fratelli, Massimo Chiari, Laura Basiricò, Henk J. Bolink, Andrea Ciavatti, Michele Sessolo, Beatrice Fraboni   +9 more
wiley   +1 more source

Metal‐Metal‐π Interaction: A Pathway to Construct Organic–Inorganic Excited‐State and Supramolecular Assembly

Advanced Optical Materials, EarlyView.
An organic–inorganic mixed excited state is designed and demonstrated by combining the metal–metal and π–π interactions within a supramolecular Pt2–pyrene assembly. Directional orbital overlap between the Pt and carbon atoms gives rise to a long‐lived triplet emission, strong emission polarization, exciton–exciton annihilation, and efficient exciton ...
Ying Luo, Yangbo Zhang, Ning Zhou, Xiong Wang, Ying‐Fan Tan, Wenjie Zou, Wei Lu, Qingyun Wan   +7 more
wiley   +1 more source

Nanocrystal Quality–Controlled Scintillation in Porous YAG:Ce Aerogels

Advanced Optical Materials, EarlyView.
High‐temperature thermal treatment of YAG:Ce nanoscintillator aerogels increases light yield under ionizing radiation by up to eightfold without affecting timing performance. Additionally, low‐temperature atmospheric treatments reversibly modify the cerium oxidation state, revealing strong defect sensitivity and offering new strategies to optimize ...
Pavlo Mai, Yannis Cheref, Raphael Marie‐Luce, Frédéric Lerouge, Julien Houel, Gilles Ledoux, Alice Perret, Francesca Cova, Mauro Fasoli, Benoit Sabot, Frédéric Chaput, Christophe Dujardin   +11 more
wiley   +1 more source

In Situ Photopolymerization of Smectic B Liquid‐Crystalline Electrolytes from Mesogenic Phosphate–Diacrylate/Ionic Liquid Complexes for High‐Performance Soft Ionic Actuators

Advanced Robotics Research, EarlyView.
A flexible liquid‐crystalline electrolyte membrane via in situ photopolymerization of a phosphate‐functionalized mesogen, ionic liquid, and diacrylate monomer is developed. The resulting smectic B (SmB)‐phase structure enables 2D ion transport with high conductivity (10−4 S cm−1).
Chengyang Liu, Masafumi Yoshio
wiley   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Interpretation of α-Pinene Mass Spectra in APCI-Like Ambient Mass Spectrometry Using GC-Coupled Atmospheric Pressure Corona Discharge Ionization. [PDF]

Mass Spectrom (Tokyo)
Ishihara R, Fukuyama D, Sekimoto K.
europepmc   +1 more source