Results 41 to 50 of about 18,724,954 (340)

Inclusion of Building‐Resolving Capabilities Into the FastEddy® GPU‐LES Model Using an Immersed Body Force Method

Journal of Advances in Modeling Earth Systems, 2020
As a first step toward achieving full physics urban weather simulation capabilities within the resident‐GPU large‐eddy simulation (LES) FastEddy® model, we have implemented and verified/validated a method for explicit representation of building effects ...
Domingo Muñoz‐Esparza, Jeremy A. Sauer, Hyeyum Hailey Shin, Robert Sharman, Branko Kosović, Scott Meech, Clara García‐Sánchez, Matthias Steiner, Jason Knievel, James Pinto, Scott Swerdlin   +10 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Cleaner fuels for ships provide public health benefits with climate tradeoffs

Nature Communications, 2018
Aerosol pollution from shipping contributes to cooling but also leads to premature mortality and morbidity. Here the authors combine emission inventories, atmospheric models and health risk functions to show how cleaner marine fuels will reduce premature
Mikhail Sofiev, James J. Winebrake, Lasse Johansson, Edward W. Carr, Marje Prank, Joana Soares, Julius Vira, Rostislav Kouznetsov, Jukka-Pekka Jalkanen, James J. Corbett   +9 more
doaj   +1 more source

Advantages of assimilating multispectral satellite retrievals of atmospheric composition: a demonstration using MOPITT carbon monoxide products [PDF]

Atmospheric Measurement Techniques
The Measurements Of Pollution In The Troposphere (MOPITT) is an ideal instrument to understand the impact of (1) assimilating multispectral and joint retrievals versus single spectral products, (2) assimilating satellite profile products versus column ...
W. Tang, B. Gaubert, L. Emmons, D. Ziskin, D. Mao, D. Edwards, A. Arellano, K. Raeder, J. Anderson, H. Worden   +9 more
doaj   +1 more source

Acceleration of the Parameterization of Unified Microphysics Across Scales (PUMAS) on the Graphics Processing Unit (GPU) With Directive‐Based Methods

Journal of Advances in Modeling Earth Systems, 2023
Cloud microphysics is one of the most time‐consuming components in a climate model. In this study, we port the cloud microphysics parameterization in the Community Atmosphere Model (CAM), known as Parameterization of Unified Microphysics Across Scales ...
Jian Sun, John M. Dennis, Sheri A. Mickelson, Brian Vanderwende, Andrew Gettelman, Katherine Thayer‐Calder   +5 more
doaj   +1 more source

The CopterSonde: an insight into the development of a smart unmanned aircraft system for atmospheric boundary layer research

Atmospheric Measurement Techniques, 2020
. The CopterSonde is an unmanned aircraft system (UAS) developed in house by a team of engineers and meteorologists at the University of Oklahoma. The CopterSonde is an ambitious attempt by the Center for Autonomous Sensing and Sampling to address the ...
Antonio R. Segales, Brian R. Greene, Tyler M. Bell, William Doyle, Joshua Martin, Elizabeth A. Pillar-Little, P. Chilson   +6 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Research Progress on Estimation of the Atmospheric Boundary Layer Height

Journal of Meteorological Research, 2020
Atmospheric boundary layer height (ABLH) is an important parameter used to depict characteristics of the planetary boundary layer (PBL) in the lower troposphere. The ABLH is strongly associated with the vertical distributions of heat, mass, and energy in
Hongsheng Zhang, Xiaoye Zhang, Qianhui Li, Xuhui Cai, S. Fan, Yu Song, F. Hu, H. Che, J. Quan, Ling Kang, Tong Zhu   +10 more
semanticscholar   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source