Results 51 to 60 of about 18,724,954 (340)

Sensitivity analysis of the meteorological preprocessor MPP-FMI 3.0 using algorithmic differentiation [PDF]

Geoscientific Model Development, 2017
The meteorological input parameters for urban- and local-scale dispersion models can be evaluated by preprocessing meteorological observations, using a boundary-layer parameterisation model.
J. Backman, C. R. Wood, M. Auvinen, M. Auvinen, L. Kangas, H. Hannuniemi, A. Karppinen, J. Kukkonen   +7 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Pilatus unmanned aircraft system for lower atmospheric research

, 2015
. This paper presents details of the University of Colorado (CU) “Pilatus” unmanned research aircraft, assembled to provide measurements of aerosols, radiation and thermodynamics in the lower troposphere.
G. Boer, S. Palo, B. Argrow, G. LoDolce, J. Mack, R. Gao, H. Telg, C. Trussel, Joshua Fromm, C. Long, G. Bland, J. Maslanik, B. Schmid, T. Hock   +13 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The next generation airborne polarimetric Doppler weather radar [PDF]

Geoscientific Instrumentation, Methods and Data Systems, 2014
Results from airborne field deployments emphasized the need to obtain concurrently high temporal and spatial resolution measurements of 3-D winds and microphysics.
J. Vivekanandan, W.-C. Lee, E. Loew, J. L. Salazar, V. Grubišić, J. Moore, P. Tsai   +6 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Climate, Variability, and Climate Sensitivity of “Middle Atmosphere” Chemistry Configurations of the Community Earth System Model Version 2, Whole Atmosphere Community Climate Model Version 6 (CESM2(WACCM6))

Journal of Advances in Modeling Earth Systems, 2023
Simulating whole atmosphere dynamics, chemistry, and physics is computationally expensive. It can require high vertical resolution throughout the middle and upper atmosphere, as well as a comprehensive chemistry and aerosol scheme coupled to radiation ...
N. A. Davis, D. Visioni, R. R. Garcia, D. E. Kinnison, D. R. Marsh, M. Mills, J. H. Richter, S. Tilmes, C. G. Bardeen, A. Gettelman, A. A. Glanville, D. G. MacMartin, A. K. Smith, F. Vitt   +13 more
doaj   +1 more source

Global Scale Inversions from MOPITT CO and MODIS AOD

Remote Sensing, 2023
Top-down observational constraints on emissions flux estimates from satellite observations of chemical composition are subject to biases and errors stemming from transport, chemistry and prior emissions estimates.
Benjamin Gaubert, David P. Edwards, Jeffrey L. Anderson, Avelino F. Arellano, Jérôme Barré, Rebecca R. Buchholz, Sabine Darras, Louisa K. Emmons, David Fillmore, Claire Granier, James W. Hannigan, Ivan Ortega, Kevin Raeder, Antonin Soulié, Wenfu Tang, Helen M. Worden, Daniel Ziskin   +16 more
doaj   +1 more source

Highly Oxygenated Organic Molecules (HOM) from Gas-Phase Autoxidation Involving Peroxy Radicals: A Key Contributor to Atmospheric Aerosol

Chemical Reviews, 2019
Highly oxygenated organic molecules (HOM) are formed in the atmosphere via autoxidation involving peroxy radicals arising from volatile organic compounds (VOC). HOM condense on pre-existing particles and can be involved in new particle formation.
Federico Bianchi, T. Kurtén, M. Riva, C. Mohr, M. Rissanen, P. Roldin, T. Berndt, J. Crounse, P. Wennberg, T. Mentel, J. Wildt, H. Junninen, T. Jokinen, M. Kulmala, D. Worsnop, J. Thornton, N. Donahue, H. Kjaergaard, M. Ehn   +18 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source