Results 71 to 80 of about 18,724,954 (340)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Reversing ocean acidification along the Great Barrier Reef using alkalinity injection

Environmental Research Letters, 2021
The Great Barrier Reef (GBR) is a globally significant coral reef system supporting productive and diverse ecosystems. The GBR is under increasing threat from climate change and local anthropogenic stressors, with its general condition degrading over ...
Mathieu Mongin, Mark E Baird, Andrew Lenton, Craig Neill, John Akl   +4 more
doaj   +1 more source

Spectrometer for Sky-Scanning Sun-Tracking Atmospheric Research (4STAR): Instrument Technology

Remote Sensing, 2013
The Spectrometer for Sky-Scanning, Sun-Tracking Atmospheric Research (4STAR) combines airborne sun tracking and sky scanning with diffraction spectroscopy to improve knowledge of atmospheric constituents and their links to air-pollution/climate.
S. Dunagan, Roy Johnson, J. Zavaleta, P. Russell, B. Schmid, C. Flynn, J. Redemann, Y. Shinozuka, J. Livingston, M. Segal-Rosenhaimer   +9 more
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A long-term high-resolution air quality reanalysis with a public-facing air quality dashboard over the Contiguous United States (CONUS) [PDF]

Earth System Science Data
We present a 14-year, 12 km, hourly air quality dataset (https://doi.org/10.5065/cfya-4g50, Kumar and He, 2023) created by assimilating satellite observations of aerosol optical depth (AOD) and carbon monoxide (CO) in an air quality model to fill gaps in
R. Kumar, P. Bhardwaj, P. Bhardwaj, C. He, J. Boehnert, F. Lacey, S. Alessandrini, K. Sampson, M. Casali, S. Swerdlin, O. Wilhelmi, G. G. Pfister, B. Gaubert, H. Worden   +13 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The Chemistry Mechanism in the Community Earth System Model Version 2 (CESM2)

Journal of Advances in Modeling Earth Systems, 2020
The Community Earth System Model version 2 (CESM2) includes a detailed representation of chemistry throughout the atmosphere in the Community Atmosphere Model with chemistry and Whole Atmosphere Community Climate Model configurations.
Louisa K. Emmons, Rebecca H. Schwantes, John J. Orlando, Geoff Tyndall, Douglas Kinnison, Jean‐François Lamarque, Daniel Marsh, Michael J. Mills, Simone Tilmes, Charles Bardeen, Rebecca R. Buchholz, Andrew Conley, Andrew Gettelman, Rolando Garcia, Isobel Simpson, Donald R. Blake, Simone Meinardi, Gabrielle Pétron   +17 more
doaj   +1 more source