Results 91 to 100 of about 5,314,366 (372)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

Terrane Boundary Geophysical Signatures in Northwest Panay, Philippines: Results from Gravity, Seismic Refraction and Electrical Resistivity Investigations

Terrestrial, Atmospheric and Oceanic Sciences, 2015
Northwest Panay consists of two terranes that form part of the Central Philippine collision zone: Buruanga Peninsula and Antique Range. The Buruanga Peninsula consists of a Jurassic chert-clastic-limestone sequence, typical of oceanic plate stratigraphy ...
Jillian Aira S. Gabo, Carla B. Dimalanta, Graciano P. Yumul Jr., Decibel V. Faustino-Eslava, and Akira Imai   +4 more
doaj   +1 more source

Atmospheric Science and Remote Sensing Laboratory [PDF]

During the contract year, scientific research on lightning and lightning hazards was carried out for the Atmospheric Electricity Group in the MSFC Remote Sensing Branch (ED43).
Bowdie, David, Mach, Douglas
core   +1 more source

Exploring Planets with Directed Aerial Robot Explorers [PDF]

, 2004
Global Aerospace Corporation (GAC) is developing a revolutionary system architecture for exploration of planetary atmospheres and surfaces from atmospheric altitudes. The work is supported by the NASA Institute for Advanced Concepts (NIAC).
Aaron, Kim M., Heun, Matthew K., Ingersoll, Andrew P., Lorenz, Ralph D., Nock, Kerry T., Pankine, Alexey A., Schlaifer, R. Stephen   +6 more
core  

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Preface to the Special Issue on "Earth Observations and Societal Impacts"

Terrestrial, Atmospheric and Oceanic Sciences, 2015
We would like to present, with great pleasure, a special issue volume on _ Observations and Societal _ This special issue is part of the the journal Terrestrial, Atmospheric and Oceanic Sciences (TAO), and is devoted to The International Conference on ...
Yuei-An Liou, Chyi-Tyi Lee, Chung-Ru Ho, and Ming-Hsu Li   +3 more
doaj   +1 more source

Exomars entry and descent science [PDF]

, 2008
The entry, descent and landing of ExoMars offer a rare (once-per-mission) opportunity to perform in situ investigation of the martian environment over a wide altitude range.
Aboudan, A., Angrilli, F., Ball, A. J., Colombatti, G., Ferri, F., Hathi, B., Leese, M. R., Lewis, S. R., Müller-Wodarg, I., Zarnecki, J. C.   +9 more
core  

Sling effect in collisions of water droplets in turbulent clouds

, 2006
We describe and evaluate the contribution of sling effect into the collision rate of the same-size water droplets in turbulent clouds. We show that already for Stokes numbers exceeding 0.2 the sling effect gives a contribution comparable to Saffman ...
Alain Pumir, Balkovsky, Bec, Bec, Chun, Chun, Derevyanko, Dodin, Falkovich, Falkovich, Franklin, Girimaji, Grabowski, Gregory Falkovich, Grits, Jaczewski, Jonas, Kostinski, Maxey, McFarquhar, Pumir, Reade, Saffman, Shaw, Squires, Sundaram, Vaillancourt, Wang, Wang, Wang, Wang, Wilkinson, Wilkinson, Wilkinson   +33 more
core   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source