Results 91 to 100 of about 5,276,046 (373)
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, EarlyView.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
Terrestrial, Atmospheric and Oceanic Sciences, 2015 Espichel-Sines is an embayed coast in SW Portugal, consisting of two capes at both extremities, a tidal inlet and associated ebb tidal delta, a barrier spit, sandy beaches, sea cliffs, and a submarine canyon.
Xiaoqin Du +3 more
doaj +1 more source
The following types of experiments for a proposed Space Station Microgravity Particle Research Facility are described: (1) growth of liquid water drop populations; (2) coalescence; (3) drop breakup; (4) breakup of freezing drops; (5) ice nucleation for ...
Ackerman, Thomas +7 more
core +1 more source
Exploring Planets with Directed Aerial Robot Explorers [PDF]
, 2004 Global Aerospace Corporation (GAC) is developing a revolutionary system architecture for exploration of planetary atmospheres and surfaces from atmospheric altitudes. The work is supported by the NASA Institute for Advanced Concepts (NIAC).
Aaron, Kim M. +6 more
core
FEBS Open Bio, EarlyView.TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo +11 more
wiley +1 more source
Atmospheric Science and Remote Sensing Laboratory [PDF]
During the contract year, scientific research on lightning and lightning hazards was carried out for the Atmospheric Electricity Group in the MSFC Remote Sensing Branch (ED43).
Bowdie, David, Mach, Douglas
core +1 more source
Sling effect in collisions of water droplets in turbulent clouds
, 2006 We describe and evaluate the contribution of sling effect into the collision rate of the same-size water droplets in turbulent clouds. We show that already for Stokes numbers exceeding 0.2 the sling effect gives a contribution comparable to Saffman ...
Alain Pumir +33 more
core +1 more source
FEBS Open Bio, EarlyView.Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr +5 more
wiley +1 more source
The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions
FEBS Open Bio, EarlyView.Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh +2 more
wiley +1 more source
Why airborne transmission hasn't been conclusive in case of COVID-19? An atmospheric science perspective. [PDF]
Sci Total Environ, 2021 Ram K +10 more
europepmc +1 more source