Results 151 to 160 of about 14,328 (280)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Sulfonated, Disulfide-Bridged Polymer Networks for Atmospheric Water Harvesting. [PDF]

Small
Dale JJ, Schweng P, Gerbaud M, Woodward RT.   +3 more
europepmc   +1 more source

Pumping and sliding of droplets steered by a hydrogel pattern for atmospheric water harvesting. [PDF]

Natl Sci Rev, 2023
Zhang W, Ji Q, Zhang G, Gu Z, Wang H, Hu C, Liu H, Ren ZJ, Qu J.   +8 more
europepmc   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Atmospheric Water Harvesting Using Thermoelectric Peltier Coolers: Single Module and Prototype Characterizations and Design [PDF]

Atmospheric water harvesting is a promising technology that offers a sustainable solution to the water scarcity problem faced by many regions around the world.
Cano Perez, Jose A.
core  

Scalable hierarchical textile fibers toward personalized wearable atmospheric water harvesting. [PDF]

Sci Adv
Lei C, Zhang Y, He L, Wang Y, Wu J, Guan W, Zhao Y, Fu Q, Johnston KP, Wu K, Yu G.   +10 more
europepmc   +1 more source

Multivariate MOF for optimizing atmospheric water harvesting

Green Energy & Environment, 2022
Ao Ma, Hengjiang Cong, Hexiang Deng
openaire   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Mechanistic and Life-Cycle Framework for Green Nanomaterials in Atmospheric Water Harvesting. [PDF]

Nanomaterials (Basel)
Al-Sadeq N, Abdullah JAA, Romero A, Perez-Puyana VM.   +3 more
europepmc   +1 more source