Results 21 to 30 of about 64,060 (275)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Efficient photoionization for barium ion trapping using a dipole-allowed resonant two-photon transition

, 2011
Two efficient and isotope-selective resonant two-photon ionization techniques for loading barium ions into radio-frequency (RF)-traps are demonstrated.
A. Friedenauer, A. Friedenauer, A.V. Steele, B. Wang, C. Cormick, C. Schneider, C. Schneider, C.-w. Chou, C.W. Chou, D. Stick, D.J. Armstrong, D.J. Wineland, D.M. Lucas, D.R. Leibrandt, F. Diedrich, G. Leschhorn, G.S. Hurst, H. Haeffner, H.J. Metcalf, J.P. Home, L. Deslauriers, M. Albert, M. Brownnutt, M. Cetina, M. Johanning, M. Krych, M.D. Davidson, N. Kjaergaard, P.E.G. Baird, Q.A. Turchette, R. Hendricks, R. Leeuwen van, R.D. Hudson, S. Gulde, S. Kahra, T. Hasegawa, T. Rosenband, T. Schaetz, T. Schaetz, U. Schramm, U. Schramm, U. Tanaka, W. Paul   +42 more
core   +1 more source

Directional `superradiant' collisions: bosonic amplification of atom pairs emitted from an elongated Bose-Einstein condensate [PDF]

, 2002
We study spontaneous directionality in the bosonic amplification of atom pairs emitted from an elongated Bose-Einstein condensate (BEC), an effect analogous to `superradiant' emission of atom-photon pairs.
A. Vardi, J. Javanainen, K. Helmerson, M. G. Moore, X. X. Yi   +4 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Spontaneous Emission in a Matter-Wave Open Quantum System

, 2017
One of the paradigms of a small quantum system in a dissipative environment is the decay of an excited atom undergoing spontaneous photon emission into the fluctuating quantum electrodynamic vacuum.
Krinner, Ludwig, Kwon, Joonhyuk, Pazmino, Arturo, Schneble, Dominik, Stewart, Michael   +4 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Laser pulse amplification and dispersion compensation in an effectively extended optical cavity containing Bose-Einstein condensates

, 2013
We review and critically evaluate our proposal of a pulse amplification scheme based on two Bose-Einstein condensates inside the resonator of a mode-locked laser. Two condensates are used for compensating the group velocity dispersion.
Mustecaplioglu, Ozgur E., Sennaroglu, Alphan, Tarhan, Devrim   +2 more
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Emission spectra and intrinsic optical bistability in a two-level medium

, 2010
Scattering of resonant radiation in a dense two-level medium is studied theoretically with account for local field effects and renormalization of the resonance frequency.
A. Kuditcher, A. Nick Vamivakas, C.M. Bowden, C.M. Bowden, D. V. Kuznetsov, D.R. Gamelin, D.V. Novitsky, E.B. Flagg, F. Ciccarello, F. Ciccarello, F.A. Hopf, J.M. Ward, K.D. Zhu, L. Li, L. Li, M. Fleischhauer, M. G. Gladush, M. Gladush, M. Gladush, M.A. Noginov, M.E. Crenshaw, M.G. Benedict, M.P. Hehlen, M.P. Hehlen, M.P. Hehlen, O. Astafiev, O. Guillot-Noël, O. Guillot-Noël, O. Guillot-Noël, P. de Vries, S. Ates, S.M. Redmond, S.R. Lüthi, Vl. K. Roerich, Y. Ben-Aryeh, Y. Ben-Aryeh, Y. Gu   +36 more
core   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source