Results 51 to 60 of about 65,256 (288)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Circuit Quantum Electrodynamics: Coherent Coupling of a Single Photon to a Cooper Pair Box

, 2004
Under appropriate conditions, superconducting electronic circuits behave quantum mechanically, with properties that can be designed and controlled at will. We have realized an experiment in which a superconducting two-level system, playing the role of an
A Blais, A Blais, A Kiraz, A. Blais, A. Wallraff, AJ Berkley, C Weisbuch, C-P Yang, D Vion, D Walls, D. I. Schuster, EK Irish, F Marquardt, F Plastina, G Nogues, H Mabuchi, I Chiorescu, J Raimond, J Vuckovic, J. Majer, JM Martinis, JQ You, K Lehnert, L Childress, L. Frunzio, O Buisson, PK Day, R. J. Schoelkopf, R.- S. Huang, RJ Thompson, S. Kumar, S. M. Girvin, T Yamamoto, V Bouchiat, WA Al-Saidi, Y Makhlin, Y Nakamura   +36 more
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

High-flux source system for matter-wave interferometry exploiting tunable interactions

Physical Review Research
Atom interferometers allow determining inertial effects to high accuracy. Quantum-projection noise as well as systematic effects impose demands on large atomic flux as well as ultralow expansion rates.
A. Herbst, T. Estrampes, H. Albers, V. Vollenkemper, K. Stolzenberg, S. Bode, E. Charron, E. M. Rasel, N. Gaaloul, D. Schlippert   +9 more
doaj   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

1.4 million Q factor Si₃N₄ micro-ring resonator at 780 nm wavelength for chip-scale atomic systems

Optics Express, 2020
A silicon nitride micro-ring resonator with a loaded Q factor of 1.4 × 106 at 780 nm wavelength is demonstrated on silicon substrates. This is due to the low propagation loss waveguides achieved by optimization of waveguide sidewall interactions and top cladding refractive index. Potential applications include laser frequency stabilization allowing for
Martin Sinclair, Kevin Gallacher, Marc Sorel, Joseph C. Bayley, Euan McBrearty, Ross W. Millar, Stefan Hild, Douglas J. Paul   +7 more
openaire   +3 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Fermions on atom chips

, 2011
We review our recent and ongoing work with Fermi gases on an atom chip. After reviewing some statistical and thermodynamic properties of the ideal, non-interacting Fermi gas, and a brief description of our atom chip and its capabilities, we discuss our ...
Aubin, Seth, Bardon, Alma B., Extavour, Marcius H. T., LeBlanc, Lindsay J., McKeever, Jason, Myrskog, Stefan, Schumm, Thorsten, Thywissen, Joseph H.   +7 more
core   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source