Results 61 to 70 of about 37,970 (297)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Assessment of Saccharomyces cerevisiae Survival Upon Exposure to Transient High Pressure and Temperature in a High-Intensity Shock Tube for Astrobiology (HISTA)

Bio-Protocol
Understanding microbial survival under extreme planetary conditions is critical for astrobiology and stress biology. Several experimental platforms, including radiation, desiccation, and microgravity, have been used to mimic extraterrestrial environments;
Riya Dhage, Arijit Roy, Bhalamurugan Sivaraman, Purusharth Rajyaguru   +3 more
doaj   +1 more source

Physics through the 1990s: Atomic, molecular and optical physics [PDF]

, 1986
The volume presents a program of research initiatives in atomic, molecular, and optical physics. The current state of atomic, molecular, and optical physics in the US is examined with respect to demographics, education patterns, applications, and the US ...

core  

Robustness of nonadiabatic holonomic gates

, 2012
10.1103/PhysRevA.86.062322Physical Review A - Atomic, Molecular, and Optical Physics866 ...
Johansson, Markus, Sjöqvist, Erik, Singh, Kuldip, Sjöqvist, Erik,, Tong, D. M., Singh, Kuldip,, Johansson, M., Hessmo, B., Tong, D.M., Johansson, Markus,, Ericsson, Marie,, Ericsson, M., Tong, Dianmin,, Ericsson, Marie, Singh, K., Hessmo, Björn,, Andersson, L. Mauritz,, Sjöqvist, E., Andersson, L.M., Hessmo, Bjoern, Andersson, Mauritz,   +20 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

An optically guided atomic fountain [PDF]

, 1999
This thesis describes the development of a laser-cooling experiment aimed at efficient transfer of cold atoms over a short distance, for loading into a conservative atom trap.
Davies, Hilary Jane, Davies, H.J.
core  

Hyperfine structure investigation of Os-187 atomic levels via optical-optical double resonance

, 2010
Optical-optical double resonance spectroscopy has been applied to measure the hyperfine structure of spectral line pairs of atomic osmium in the visible wavelength range.
Guthoehrlein, Guenter H., Başar, Günay, Basar, Gönül, Kroeger, Sophie   +3 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

NOVEL ANALYTIC-NUMERICAL MODEL OF FREE CONVECTION: WITH LEADING EDGE CONSIDERED

TASK Quarterly, 2014
A novel solution of the free convection boundary problem is represented in analytical form for velocity and temperature for an isothermal vertical plate, as an example.
SERGEY LEBLE, WITOLD M. LEWANDOWSKI
doaj   +1 more source