Results 141 to 150 of about 6,623 (297)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Atomic clock using a photodetector [PDF]
, 2015 In one embodiment, an atomic clock for use in an electronic device includes a photodetector with a single-isotope silicon crystal doped with impurity atoms in which a photocurrent generated via a two-photon process within the photodetector is used as a ...
Karaiskaj, Denis
core +1 more source
A compact cold-atom microwave clock prototype [PDF]
The transfer of quantum technologies from research laboratories into practical, compact devices brings with it the promise of enhancing a variety of real-world applications.
Knapp, Martin
core +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Research on Pressure Compensation for the Rubidium Atomic Clock Working in Atmospheric Environment
Chinese Journal of Magnetic ResonanceVapor cell rubidium atomic clock is widely used in the fields of satellite navigation and communication with advantages including small size, light weight, low power and maintenance cost.
LI Junyao +8 more
doaj +1 more source
Fisher information and optimal measurement of Rabi spectrum in optical lattice atomic clocks [PDF]
Ruo-Shui Han, Guixin Tang, Tao Wang
openalex +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Proposed combination atomic oscillator and frequency divider, using amplifiers at divided frequencies, applied to an atomic clock [PDF]
This image is part of the Atomic Clock collection. The Atomic Clock collection is comprised of images documenting the development of the atomic clocks that were part of the National Bureau of Standards (NBS) Atomic Time System.
National Institute of Standards and Technology and Technology
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source