Results 81 to 90 of about 37,255 (283)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Competing bounds on the present-day time variation of fundamental constants

, 2008
We compare the sensitivity of a recent bound on time variation of the fine structure constant from optical clocks with bounds on time varying fundamental constants from atomic clocks sensitive to the electron-to-proton mass ratio, from radioactive decay ...
Christof Wetterich, M. T. Murphy, Steffen Stern, Thomas Dent   +3 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Magnetic field-induced spectroscopy of forbidden optical transitions with application to lattice-based optical atomic clocks

, 2005
We develop a method of spectroscopy that uses a weak static magnetic field to enable direct optical excitation of forbidden electric-dipole transitions that are otherwise prohibitively weak.
A. Taichenachev, C. Hoyt, C. Oates, H. Katori, L. Allen, L. Hollberg, M. A. Bouchiat, V. Yudin, Z. Barber, Z. W. Barber   +9 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

On possibilities of improving the accuracy of the geocentric gravitational constant GM by combining SLR and atomic clocks measurements

Contributions to Geophysics and Geodesy
Nowadays, the geocentric gravitational constant GM is determined by solving equations of motion for trajectories of artificial satellites measured by Satellite Laser Ranging (SLR). The estimated value of GM and its uncertainty 398600441.8 ± 0.8×106 m3s−2
Robert TENZER, Pavel NOVÁK, Mehdi ESHAGH   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The potential of continuous, local atomic clock measurements for earthquake prediction and volcanology

EPJ Web of Conferences, 2015
Modern optical atomic clocks along with the optical fiber technology currently being developed can measure the geoid, which is the equipotential surface that extends the mean sea level on continents, to a precision that competes with existing technology.
Bondarescu Mihai, Bondarescu Ruxandra, Jetzer Philippe, Lundgren Andrew   +3 more
doaj   +2 more sources

Search for variation of fundamental constants and violations of fundamental symmetries using isotope comparisons

, 2011
Atomic microwave clocks based on hyperfine transitions, such as the caesium standard, tick with a frequency that is proportional to the magnetic moment of the nucleus.
Berengut, J. C., Flambaum, V. V., Kava, E. M.   +2 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source