Results 141 to 150 of about 23,949,715 (384)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

New model for datasets citation and extraction reproducibility in VAMDC

, 2016
In this paper we present a new paradigm for the identification of datasets extracted from the Virtual Atomic and Molecular Data Centre (VAMDC) e-science infrastructure.
Dubernet, Marie-Lise, Moreau, Nicolas, Zwölf, Carlo Maria   +2 more
core   +3 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Toward a New Evaluation of Neutron Standards

EPJ Web of Conferences, 2016
Measurements related to neutron cross section standards and certain prompt neutron fission spectra are being evaluated. In addition to the standard cross sections, investigations of reference data that are not as well known as the standards are being ...
Carlson A.D., Pronyaev V.G., Capote R., Hale G.M., Hambsch F.-J., Kawano T., Kunieda S., Mannhart W., Nelson R.O., Neudecker D., Schillebeeckx P., Simakov S., Smith D.L., Talou P., Tao X., Wallner A., Wang W.   +16 more
doaj   +1 more source

Atomic Data from the Opacity Project [PDF]

Highlights of Astronomy, 1992
The name Opacity Project (OP) refers to an international collaboration that was formed in 1984 to calculate the extensive atomic data required to estimate stellar envelope opacities. The project has involved research groups from France, Germany, the United Kingdom, the United States and Venezuela.
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Fourier shape parameterization in covariant density functional theory for nuclear fission

Physics Letters B
We implement the Fourier shape parameterization within the point-coupling covariant density functional theory to construct the collective space, potential energy surface (PES), and mass tensor, which serve as inputs for the time-dependent generator ...
Zeyu Li, Yang Su, Lile Liu, Yongjing Chen, Zhipan Li   +4 more
doaj   +1 more source

The calculation and evaluation for n+54,56,57,58Fe reactions

EPJ Web of Conferences, 2017
All cross sections of neutron-induced reactions, angular distributions, double differential cross sections, angle-integrated spectra, γ-ray production cross sections and energy spectra for 54,56,57,58Fe are calculated by using theoretical models at ...
Han Yinlu, Xu Yongli, Guo Hairui, Zhang Zhengjun, Liang Haiying, Cai Chonghai, Shen Qingbiao   +6 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Development of multigroup cross section library generation system TPAMS

Nuclear Engineering and Technology
Kylin-2 is an advanced neutronics lattice code, developed by Nuclear Power Institute of China. High-precision multigroup cross section library is need for KYLIN-2 to carry out simulation of current pressurized water reactor (PWR) and advanced reactor. In
Lili Wen, Haicheng Wu, Ying Chen, Xiaoming Chai, Xiaofei Wu, Xiaolan Tu, Yuan Liu   +6 more
doaj   +1 more source