Results 31 to 40 of about 432,181 (251)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Atomic Energy Commission Report TID-7010
, 1957 Introduction: Atomic Energy Facts is designed to serve as an introduction to nuclear operations in the United States and as a handbook of related information for the use of industrial firms and other active or interested in atomic ...
U.S. Atomic Energy Commission
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Atomic Energy Commission Report AECD-3369
, 1952 : " The construction and operation of a dropping mercury polaroscope developed by Quentin A. Kerns is described herein. With this polaroscope a Heyrovsky polarogram is automatically produced on the screen of a cathode ray tube during the formation of ...
U.S. Atomic Energy Commission
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Atomic Energy Commission Report AECD-3792
, 1955 Report discussing the progress of various projects at the Knolls Atomic Power Laboratory during the period from March to May ...
Knolls Atomic Power Laboratory
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FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Atomic Energy Commission Report 147
, 1966 From introduction: This is one of a series of three reports on airborne radioactivity surveys in the United States. The reports contain the 185 airborne anomaly maps issued by the U. S.
U.S. Atomic Energy Commission. Grand Junction Office.
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