Results 71 to 80 of about 370,623 (293)

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Study on applicability of fast reactor plant dynamics analysis code to core thermal hydraulics under natural circulation decay heat removal conditions

Nihon Kikai Gakkai ronbunshu, 2017
A plant dynamics analysis code named Super-COPD is being developed in Japan Atomic Energy Agency (JAEA) to offer a methodology for the design and safety assessments of future commercialized sodium-cooled fast reactors (SFRs).
Erina HAMASE, Norihiro DODA, Kunihiko NABESHIMA, Ayako ONO, Hiroyuki OHSHIMA   +4 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Adsorption behavior and structural transformation mechanism of ZIF-8 material on iodine vapor with varying particle sizes

Discover Applied Sciences
Developing effective iodine capture technologies is critical for both nuclear safety and environmental protection. This study investigates the iodine adsorption properties of ZIF-8, a metal–organic framework (MOF).
Tian Lan, Xiaofan Ding, Songtao Xiao, Zhongwei Yuan, Taihong Yan, Qi Chen, Tianchi Li, Weifang Zheng   +7 more
doaj   +1 more source

Research on the Source Convergence Diagnose Method of Monte Carlo Critical Calculation for Loosely Coupled System [PDF]

EPJ Web of Conferences
In order to improve the reliability and accuracy of Monte Carlo program in the critical safety calculation of loosely coupled systems, an improved Shannon entropy diagnose method considering the distribution of fission sources and the statistical bias is
Cheng Yuting, Zhou Qi, Zhu Qingfu, Xia Zhaodong, Ning Tong, Zhang Zhengyang   +5 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

An assessment of support effect on reinforced concrete structure under inclined impact conditions

Mechanical Engineering Journal
As an outer protective engineering structure for a nuclear power plant (NPP), a reinforced concrete (RC) containment wall of NPP should be evaluated for safety requirement related to external threats.
Zuoyi KANG, Yukihiko OKUDA, Akemi NISHIDA, Haruji TSUBOTA, Masaharu ITOH   +4 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source