Results 71 to 80 of about 1,330,445 (333)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Research Progress on Long-Range α Detector

He huaxue yu fangshe huaxue, 2023
Because of the short range of α particle, the conventional α activity direct measurement method cannot detect α radioactivity of irregular surface and pipe in a large area.
ZHOU Zi-jun, DING You-qian, DANG Yun-bo, BAI Long, CUI Chun-sheng, GANG Fa-yuan   +5 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Impact simulations on local damage of reinforced concrete panel influenced by projectile nose shape

Mechanical Engineering Journal, 2020
Most impact research has been presented on the basis of impact tests and numerical analysis performed by rigid projectile impact perpendicular to the target structure. On the other hand, there are only few reports on impacts at an oblique angle.
Zuoyi KANG, Akemi NISHIDA, Yukihiko OKUDA, Haruji TSUBOTA, Yinsheng LI   +4 more
doaj   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Quantum Chemistry, Anomalous Dimensions, and the Breakdown of Fermi Liquid Theory in Strongly Correlated Systems

, 1993
We formulate a local picture of strongly correlated systems as a Feynman sum over atomic configurations. The hopping amplitudes between these atomic configurations are identified as the renormalization group charges, which describe the local physics at ...
, Cardy J L, Emery V J, Gabriel Kotliar, Haldane F D M, Haldane F D M, Haldane F D M, Hubbard J, Nelson D, Qimiao Si, Shankar R, Si Q, Vollhardt D   +12 more
core   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

High-temperature oxidation of sheath materials using mineral-insulated cables for a simulated severe accident

Mechanical Engineering Journal, 2018
In-pile instrumentation systems in present-day light water reactors (LWR) are indispensable to monitor all situations during reactor operation and reactor shut down.
Hiroko NAKANO, Noriaki HIROTA, Hiroshi SHIBATA, Tomoaki TAKEUCHI, Kunihiko TSUCHIYA   +4 more
doaj   +1 more source

A transferable artificial neural network model for atomic forces in nanoparticles

, 2018
We have designed a new method to fit the energy and atomic forces using a single artificial neural network (SANN) for any number of chemical species present in a molecular system.
Bulusu, Satya S., Jindal, Shweta
core   +1 more source