Results 81 to 90 of about 1,330,445 (333)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Stress, strain, neutron transport and radiation effects in a full fusion tokamak device: A virtual MAST-U study [PDF]

EPJ Web of Conferences
A finite-element method (FEM) model for the Mega-Ampere Spherical Tokamak - Upgrade (MAST-U) fusion tokamak has been developed to evaluate stress and deformations in the full device structure and to assess the stability of the whole tokamak with respect ...
Reali Luca, Ellis William M.E., Gray Ander, Boleininger Max, Davis Andrew, Brooks Helen M., Katramados Ioannis, Thornton Andrew J., Buchanan James, Dudarev Sergei L.   +9 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Development and validation of a GF-AAS method and its application for the trace level determination of Pb, Cd, and Cr in fish feed samples commonly used in the hatcheries of Bangladesh

Journal of Analytical Science and Technology, 2017
Background A sensitive, accurate and precise method was developed and validated in regard to Council Directive 333/2007/EC, Commission Decision 657/2002/EC, ISO/IEC 17025:2005 and EURACHEM 1998 for the trace level determination of Lead (Pb), Cadmium (Cd)
A. K. M. Atique Ullah, M. A. Maksud, S. R. Khan, L. N. Lutfa, Shamshad B. Quraishi   +4 more
doaj   +1 more source

Ab initio Study of Valley Line on a Total-Energy Surface for Zone-Center Distortions of Ferroelectric Perovskite Oxides BaTiO3 and PbTiO3

, 2004
An ab initio structure optimization technique is newly developed to determine the valley line on a total-energy surface for zone-center distortions of ferroelectric perovskite oxides and is applied to barium titanate BaTiO3 and lead titanate PbTiO3.
Hashimoto, Takatoshi, Ikeda, Yoshiaki, Kawazoe, Yoshiyuki, Mizuseki, Hiroshi, Nishimatsu, Takeshi, Sasaki, Atsushi   +5 more
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Study on applicability of fast reactor plant dynamics analysis code to core thermal hydraulics under natural circulation decay heat removal conditions

Nihon Kikai Gakkai ronbunshu, 2017
A plant dynamics analysis code named Super-COPD is being developed in Japan Atomic Energy Agency (JAEA) to offer a methodology for the design and safety assessments of future commercialized sodium-cooled fast reactors (SFRs).
Erina HAMASE, Norihiro DODA, Kunihiko NABESHIMA, Ayako ONO, Hiroyuki OHSHIMA   +4 more
doaj   +1 more source

Direct reconstruction of the effective atomic number of materials by the method of multi-energy radiography

, 2003
A direct method is proposed for reconstruction of the effective atomic number by means of multi-energy radiography of the material. The accuracy of the method is up to 95% . Advantages over conventional radiographic methods, which ensure accuracy of just
Alvarez, Barnes, Cloetens, Coenen, Craig F Smith, Feldkamp, Gog, Grodzins, Harrison, Inanc, Marziani, Rizescu, Robert-Coutant, Sergey V Naydenov, Van Geet, Vladimir D Ryzhikov, Wilkins   +16 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Study for s-process using neutron beam provided from ANNRI of J-PARC

EPJ Web of Conferences, 2016
Most isotopes heavier than iron are synthesized by the slow neutron capture reaction process (s-process) in stars. Isomers in stable isotopes have sometimes an important role as a branching point in nucleosynthesis flow in the s-process. An isomer with a
Hayakawa Takehioto, Toh Yosuke, Kimura Akira, Nakamura Shoji, Shizuma Toshiyuki, Harada Hideo   +5 more
doaj   +1 more source