Results 81 to 90 of about 8,492,929 (374)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Stress, strain, neutron transport and radiation effects in a full fusion tokamak device: A virtual MAST-U study [PDF]

EPJ Web of Conferences
A finite-element method (FEM) model for the Mega-Ampere Spherical Tokamak - Upgrade (MAST-U) fusion tokamak has been developed to evaluate stress and deformations in the full device structure and to assess the stability of the whole tokamak with respect ...
Reali Luca, Ellis William M.E., Gray Ander, Boleininger Max, Davis Andrew, Brooks Helen M., Katramados Ioannis, Thornton Andrew J., Buchanan James, Dudarev Sergei L.   +9 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Analytical study of perforation damage in reinforced concrete slabs subjected to oblique impact by projectiles with different nose shapes

Mechanical Engineering Journal, 2020
Considerable research has been carried out to establish a rational assessment method for nuclear power plants against external projectile impact. Most of the empirical formulas have been proposed to quantitatively investigate local damage to reinforced ...
Zuoyi KANG, Yukihiko OKUDA, Akemi NISHIDA, Haruji TSUBOTA, Yinsheng LI   +4 more
doaj   +1 more source

Discrepancies in Atomic Data and Suggestions for their Resolutions

, 2017
The analysis and modelling of a range of plasmas (for example: astrophysical, laser-produced and fusion), require atomic data for a number of parameters, such as energy levels, radiative rates and electron impact excitation rates, or equivalently the ...
Aggarwal, K. M.
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Occupational radiation exposure analysis in industrial radiography in Bangladesh

Radiation Medicine and Protection
Objective: To evaluate the workload management and guarantee the technical concerns for an appropriate radiation protection method in non-destructive testing (NDT) industries in Bangladesh. Methods: The radiation exposure for 721 workers was investigated
Mehedi Hassan, Shahadat Hossain, M.M. Mahfuz Siraz, Shikha Pervin, Nazneen Sultana, Md Zakir Hossain, Selina Yeasmin   +6 more
doaj   +1 more source

High-temperature oxidation of sheath materials using mineral-insulated cables for a simulated severe accident

Mechanical Engineering Journal, 2018
In-pile instrumentation systems in present-day light water reactors (LWR) are indispensable to monitor all situations during reactor operation and reactor shut down.
Hiroko NAKANO, Noriaki HIROTA, Hiroshi SHIBATA, Tomoaki TAKEUCHI, Kunihiko TSUCHIYA   +4 more
doaj   +1 more source

Atomic Model of Susy Hubbard Operators

, 2002
We apply the recently proposed susy Hubbard operators to an atomic model. In the limiting case of free spins, we derive exact results for the entropy which are compared with a mean field + gaussian corrections description.
A. Auerbach, A. Auerbach, A. Schroeder, A.A. Abrikosov, A.J. Millis, A.J. Millis, C. Jayaprakash, C. Panagopoulos, C. Pépin, C. Pépin, C.L. Kane, C.M. Varma, D. Yoshioka, D. Yoshioka, D.P. Arovas, D.P. Arovas, J. Custers, J. Gan, J. Gan, J. Gan, J. Hopkinson, J.L. Tallon, N. Read, N. Read, O. Parcollet, O. Trovarelli, P. Coleman, P. Coleman, P. Coleman, P. Coleman, P. Coleman, P. Coleman, P. Coleman, S.E. Barnes, S.E. Barnes, T.K. Ng   +35 more
core   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source