Results 231 to 240 of about 28,725 (311)

Structural insights into the roles of PARP4 and NAD⁺ binding in the human vault cage. [PDF]

Nat Commun
Lodwick JE, Shen R, Erramilli S, Xie Y, Roganowicz K, Ritchey S, Kossiakoff AA, Zhao M.   +7 more
europepmc   +1 more source

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

Ruthenium Single-Atom Nanozyme Driven Sonosensitizer with Oxygen Vacancies Enhances Electron-Hole Separation Efficacy and Remodels Tumor Microenvironment for Sonodynamic-Amplified Ferroptosis. [PDF]

Adv Sci (Weinh)
Zhu Y, Wang D, Du C, Wu T, Wei P, Zheng H, Li G, Zheng S, Su L, Yan L, Hu Y, Wang H, Lin L, Ding C, Chen X.   +14 more
europepmc   +1 more source

Photocrosslinkable Kidney Decellularized Extracellular Matrix‐Based Bioink for 3D Bioprinting

Advanced Healthcare Materials, EarlyView.
A photocrosslinkable bioink is developed from methacrylated decellularized porcine kidney extracellular matrix to create kidney‐specific 3D constructs. This bioink supports high cell viability, promotes multicellular spheroid formation, and enables stable multilayer bioprinting with tunable mechanical properties, providing a versatile platform for ...
Jaemyung Shin, Nima Tabatabaei Rezaei, Subin Choi, Zhangkang Li, Deok‐Ho Kim, Keekyoung Kim   +5 more
wiley   +1 more source

Tumor Microenvironment‐responsive Nanocatalyst for Targeted Chemodynamic Cancer Therapy

Advanced Healthcare Materials, EarlyView.
An Tumor microenvironment‐responsive nanocatalyst system composed of PLGA‐encapsulated Ca–Fe peroxide and polyarginine enables sustainable Fenton reaction in tumors. Low levels of H2O2 (50–100 µm) initiate the nanoparticle degradation, while polyarginine‐derived nitric oxide accelerates Fe3+ reduction, leading to self‐amplifying •OH generation for ...
Jun Ma, Jingjing Qiu, Shiren Wang
wiley   +1 more source

A Targeted Redox‐Active Dual‐Action Pt(IV)‐Mn(II) Prodrug Displays Enhanced In Vivo Anticancer Activity

Advanced Healthcare Materials, EarlyView.
A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez, Henri Chédotal, Ram Pravin Kumar Muthuramalingam, Marine Thomas, Jia Ning Nicolette Yau, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Kadda Medjoubi, Andrea Somogyi, Giulia Adriani, Carole Nicco, Romain Coriat, Giorgia Pastorin, Hélène C. Bertrand   +14 more
wiley   +1 more source

Platinum Stabilises a Molten-Globule Conformation of a Small Globular Cytosolic Protein SUMO1. [PDF]

Chem Asian J
Tiwari S, Koti Ainavarapu SR.
europepmc   +1 more source

Anomalous Water Fluorescence Induced by Solutes. [PDF]

J Phys Chem Lett
Villa AM, Di Paola J, Ami D, De Gioia L, Natalello A, Bertini L.   +5 more
europepmc   +1 more source

Africa, an Emerging Exporter of Turmeric: Combating Fraud with Rapid Detection Systems. [PDF]

Foods
Abia WA, Haughey SA, Radhika R, Taty BP, Russell H, Carey M, Maestroni BM, Petchkongkaew A, Elliott CT, Williams PN.   +9 more
europepmc   +1 more source