Si Inhibited Osteoclastogenesis: The Role of Fe and the Fenton Reaction
Silicate (Si) inhibition of osteoclastogenesis, is mediated by Fe. Si chemical interactions with Fe inhibit the Fenton reaction and intercellular ROS availability. This reduction in ROS availability inhibits osteoclastogenesis. The addition of Fe, in Si‐inhibited osteoclast cultures, restores the Fenton reaction, and osteoclastogenesis.
Yutong Li+7 more
wiley +1 more source
Higher BODIPY Homologues-Synthesis, Reactivity, and Photoluminescence Investigations. [PDF]
Erlemeier L+5 more
europepmc +1 more source
Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum+28 more
wiley +1 more source
Utility of unique optical properties of Anethum graveolens green synthesized mediated-alumina nanoparticles for spectrofluorometric determination of darifenacin in pharmaceutical products. [PDF]
Alterary SS+3 more
europepmc +1 more source
Determination of total arsenic in seawater by hydride generation atomic fluorescence spectrometry
Carolina Lyrio T. Correia+4 more
openalex +1 more source
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi+10 more
wiley +1 more source
Platinum Stabilises a Molten-Globule Conformation of a Small Globular Cytosolic Protein SUMO1. [PDF]
Tiwari S, Koti Ainavarapu SR.
europepmc +1 more source
Tumor Microenvironment‐responsive Nanocatalyst for Targeted Chemodynamic Cancer Therapy
An Tumor microenvironment‐responsive nanocatalyst system composed of PLGA‐encapsulated Ca–Fe peroxide and polyarginine enables sustainable Fenton reaction in tumors. Low levels of H2O2 (50–100 µm) initiate the nanoparticle degradation, while polyarginine‐derived nitric oxide accelerates Fe3+ reduction, leading to self‐amplifying •OH generation for ...
Jun Ma, Jingjing Qiu, Shiren Wang
wiley +1 more source
Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides. [PDF]
Valli D+7 more
europepmc +1 more source