Results 61 to 70 of about 770,384 (397)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

SNAREs: Could They be the Answer to an Energy Landscape Riddle in Exocytosis?

The Scientific World Journal, 2010
During exocytosis, chemical transmitters stored in secretory vesicles can be released upon fusion of these intracellular organelles to the plasma membrane. In this process, SNARE proteins that form a ternary core complex play a central role. This complex
Wei Liu, Vladimir Parpura
doaj   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Pectin Nanostructure Visualization by Atomic Force Microscopy

Bio-Protocol, 2015
Pectins, complex polysaccharides rich in galacturonic acid, are a major component of primary plant cell walls. These macromolecules regulate cell wall porosity and intercellular adhesion, being important in the control of cell expansion and ...
Sara Posé, Candelas Paniagua, Andrew Kirby, A. Gunning, Victor Morris, Miguel Quesada, Jose Mercado   +6 more
doaj   +1 more source

Interaction imaging with amplitude-dependence force spectroscopy

, 2013
Knowledge of surface forces is the key to understanding a large number of processes in fields ranging from physics to material science and biology. The most common method to study surfaces is dynamic atomic force microscopy (AFM).
A San Paulo, AC Hindmarsh, AJ Katan, B Luan, BJ Albers, BV Derjaguin, D Platz, EA Tholén, F Jamitzky, FJ Giessibl, H Hölscher, H Hölscher, HJ Mamin, IN Sneddon, J Legleiter, J Melcher, J Melcher, JE Sader, JL Arlett, JP Cleveland, K Jensen, L Mininni, M Dong, M Lee, M Li, M Stark, MD LaHaye, MJ Higgins, MT Cuberes, MZ Baykara, O Sahin, O Sahin, R Garcia, R Garcia, RW Stark, S Basak, S Hu, S Hu, S Jesse, S Walheim, U Dürig, U Dürig, Y Seo   +42 more
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

High-precision atomic force microscopy with atomically-characterized tips

New Journal of Physics, 2020
Traditionally, atomic force microscopy (AFM) experiments are conducted at tip–sample distances where the tip strongly interacts with the surface. This increases the signal-to-noise ratio, but poses the problem of relaxations in both tip and sample that ...
A Liebig, A Peronio, D Meuer, A J Weymouth, F J Giessibl   +4 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Noise reduction in atomic force microscopy: Resonance contact mode [PDF]

, 1996
Noise reduction has been accomplished in atomic force microscopy by applying a high frequency, low amplitude vibration to the cantilever while it is in contact with a surface.
Baldeschwieler, J. D., Eby, R. K., Gamble, R. C., O'Connor, S. D.   +3 more
core   +1 more source

Effect of Actin Organization on the Stiffness of Living Breast Cancer Cells Revealed by Peak-Force Modulation Atomic Force Microscopy.

ACS Nano, 2016
We study the correlation between cytoskeleton organization and stiffness of three epithelial breast cancer cells lines with different degrees of malignancy: MCF-10A (healthy), MCF-7 (tumorigenic/noninvasive), and MDA-MB-231 (tumorigenic/invasive).
A. Calzado-Martín, M. Encinar, J. Tamayo, M. Calleja, Á. San Paulo   +4 more
semanticscholar   +1 more source